Description
Alfa D3-TEVA (alfacalcidol) Capsules 0.5 mcg. №30
Composition
Alfacalcidol is the active ingredient in Alfa D3-TEVA capsules. Each capsule contains 0.5 mcg of alfacalcidol along with other inactive ingredients.
Mechanism of Action
Alfacalcidol, a synthetic analogue of vitamin D, exerts its pharmacological effects by enhancing intestinal absorption of calcium and promoting bone mineralization. It acts as a prohormone that undergoes metabolic activation in the liver and kidneys to stimulate calcium and phosphorus metabolism.
Pharmacological Properties
Alfacalcidol functions as a potent regulator of calcium homeostasis by increasing calcium absorption in the intestines and reducing renal excretion of calcium. It also plays a vital role in maintaining bone health by promoting mineralization and inhibiting bone resorption.
Indications for Use
- Management of hypocalcemia associated with hypoparathyroidism
- Treatment of metabolic bone diseases such as osteoporosis
Contraindications
Do not use Alfa D3-TEVA if you have a known hypersensitivity to alfacalcidol or any of the inactive ingredients present in the capsules. Use caution in patients with hypercalcemia, vitamin D toxicity, or renal impairment.
Side Effects
Common side effects of Alfa D3-TEVA may include hypercalcemia, hypercalciuria, gastrointestinal disturbances, and skin reactions. Severe adverse reactions such as renal impairment or cardiac arrhythmias are rare but possible with high doses or prolonged use.
Usage Instructions
The recommended dosage of Alfa D3-TEVA capsules should be individualized based on the patient’s condition and response to treatment. Typically, it is taken orally once daily with or without food. Avoid exceeding the prescribed dose to minimize the risk of adverse effects.
Benefits Compared to Analogues
Alfa D3-TEVA offers a more targeted approach to managing calcium and bone disorders compared to traditional vitamin D supplements. Its specific activation pathway and enhanced potency make it a preferred choice for individuals with impaired vitamin D metabolism or those requiring precise control of calcium levels.
Suitable Patient Groups
Alfa D3-TEVA is suitable for adults of all ages, including elderly individuals with osteoporosis or hypoparathyroidism. It may also be used in pediatric patients under close medical supervision for specific indications such as rickets or vitamin D deficiency.
Storage and Shelf Life
Store Alfa D3-TEVA capsules in a cool, dry place away from direct sunlight. Ensure proper sealing of the packaging to protect the capsules from moisture. Check the expiration date on the label and discard any expired or damaged capsules.
Packaging Description
Alfa D3-TEVA capsules are supplied in blister packs containing 30 capsules each. The packaging is designed to maintain the stability and integrity of the capsules throughout the shelf life. Each blister is labeled with essential product information for easy identification.
Clinical Evidence and Proven Effectiveness
Alfacalcidol supplementation has been extensively studied in various clinical trials, demonstrating its efficacy in improving calcium levels, bone mineral density, and reducing fracture risk in patients with osteoporosis and other bone disorders. Notably, research published in the Journal of Bone and Mineral Research has highlighted the positive impact of alfacalcidol on skeletal health and fracture prevention in postmenopausal women.
