Description
Almer (Donepezil Hydrochloride) Coated Tablets 10 mg. №30
Ingredients
Active ingredient: Donepezil hydrochloride 10 mg.
Mechanism of Action
Donepezil hydrochloride, the active ingredient in Almer tablets, is a cholinesterase inhibitor. It functions by increasing the levels of acetylcholine in the brain. Acetylcholine, a neurotransmitter reduced in individuals with Alzheimer’s disease, is critical for cognitive function. By inhibiting acetylcholine breakdown, donepezil enhances cognitive function, memory, and daily functioning in Alzheimer’s patients.
Pharmacological Properties
Donepezil hydrochloride acts as a selective and reversible inhibitor of acetylcholinesterase, the enzyme responsible for acetylcholine hydrolysis. This action leads to increased acetylcholine levels in the synaptic cleft, promoting neurotransmission and cognitive processes in Alzheimer’s disease.
Indications for Use
Indications: Almer tablets are indicated for the treatment of mild to moderate dementia associated with Alzheimer’s disease.
Contraindications
Contraindications: Avoid using Almer tablets if you have a known allergy to donepezil or any components of the tablet formulation.
Side Effects
Common side effects of Almer tablets may include nausea, diarrhea, insomnia, and muscle cramps. In case of severe side effects or allergic reactions, seek immediate medical attention.
Usage Instructions
Dosage: The recommended dose is 10 mg once daily, typically taken at bedtime. Swallow the tablet whole with water; do not crush or chew it.
Benefits Compared to Analogues
Almer tablets offer the advantage of effectively improving cognitive function and slowing symptom progression in Alzheimer’s disease patients. Compared to other treatments, Almer has demonstrated significant cognitive enhancement and better overall daily functioning.
Suitable Patient Groups
Almer tablets are suitable for adults with mild to moderate Alzheimer’s disease. Consult a healthcare provider for appropriate dosing in special populations such as the elderly or those with hepatic or renal impairment.
Storage and Shelf Life
Store Almer tablets in a cool, dry place below 25°C. Keep them in the original packaging to protect from moisture. Check the expiration date on the packaging and do not use expired tablets.
Packaging Description
Almer tablets are available in a pack of 30 coated tablets, each containing 10 mg of donepezil hydrochloride. The packaging is designed to ensure the integrity and safety of the tablets.
Scientific Evidence
Clinical trials have proven the efficacy of donepezil in enhancing cognitive function and slowing Alzheimer’s disease progression. A study in the New England Journal of Medicine reported significant cognitive improvement with donepezil compared to placebo in mild to moderate Alzheimer’s patients.
