Description
Amoxiclav (Amoxicillin) Powder for Suspension 125 mg/31.25 mg. 5 ml. 100 ml. Vial
Ingredients:
Each 5 ml of reconstituted suspension contains 125 mg of amoxicillin and 31.25 mg of clavulanic acid.
Mechanism of Action:
Amoxiclav is a combination antibiotic containing amoxicillin, a penicillin-class antibiotic, and clavulanic acid, a beta-lactamase inhibitor. Clavulanic acid enhances the activity of amoxicillin by protecting it from beta-lactamase enzymes produced by some bacteria, thus extending the spectrum of activity against a broader range of pathogens.
Pharmacological Properties:
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death. Clavulanic acid inhibits beta-lactamases, enzymes that can inactivate antibiotics like amoxicillin, thereby restoring amoxicillin’s antibacterial activity against resistant bacteria.
Indications for Use:
Amoxiclav is indicated for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media, and sinusitis caused by susceptible pathogens.
Contraindications:
Avoid using Amoxiclav if you have a history of hypersensitivity reactions to penicillins, cephalosporins, or other beta-lactam antibiotics. Consult your healthcare provider for suitable alternative treatment options.
Side Effects:
Common side effects of Amoxiclav may include diarrhea, nausea, vomiting, skin rash, and allergic reactions. Contact your doctor if you experience severe or persistent side effects.
Usage Instructions:
Shake the suspension well before each use. The dosage for adults and children varies based on the severity of the infection. Follow the specific instructions provided by your healthcare provider for reconstitution and administration. Do not exceed the recommended dosage or discontinue the medication prematurely.
Benefits Compared to Analogues:
Amoxiclav offers an advantage over traditional amoxicillin by incorporating clavulanic acid, which extends its antibacterial spectrum and effectiveness against beta-lactamase-producing bacteria, providing a broader coverage of pathogens.
Suitable Patient Groups:
Amoxiclav can be used in both adult and pediatric populations, with dosages adjusted based on weight and severity of the infection. Elderly patients may require dosage adjustments based on renal function.
Storage Conditions and Shelf Life:
Store Amoxiclav powder for suspension in a cool, dry place away from direct sunlight. Follow the storage instructions on the packaging. Once reconstituted, the suspension should be stored in the refrigerator and discarded after the specified number of days as indicated in the product information.
Packaging Description:
Amoxiclav is supplied as a powder for suspension in a vial containing 100 ml of the product. The packaging should include detailed instructions on reconstitution, dosage calculation, and administration to ensure proper use of the medication.
Scientific Evidence:
Amoxiclav, a combination of amoxicillin and clavulanic acid, has been extensively studied for its efficacy in treating various bacterial infections. Research has shown that the addition of clavulanic acid enhances the activity of amoxicillin against beta-lactamase-producing bacteria, increasing its effectiveness.
Additional Information:
Completing the full course of treatment with Amoxiclav as prescribed is crucial to eradicate the infection and prevent antibiotic resistance. If you encounter severe side effects or allergic reactions, seek immediate medical attention. Consult your healthcare provider for personalized guidance on medication use, potential interactions, and precautions. Keep the medication out of reach of children and follow proper storage guidelines.
