Description
Citozar (Cytarabine) Powder for Solution 1000 mg. №1 Vial
Ingredients
Active Ingredient: Cytarabine
Inactive Ingredients: Mannitol, Sodium Hydroxide, and Hydrochloric Acid.
Mechanism of Action
Cytarabine inhibits DNA synthesis in rapidly dividing cells, exerting its cytotoxic effects and leading to cell death. This mechanism is pivotal in the treatment of leukemia.
Pharmacological Properties
Cytarabine exerts its cytotoxic effects by disrupting DNA synthesis, making it particularly effective against rapidly dividing cells. This property underpins its essential role in leukemia treatment.
Indications for Use
Citozar (Cytarabine) is indicated for the treatment of various types of leukemia, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
Contraindications
Citozar (Cytarabine) is contraindicated in patients with known hypersensitivity to cytarabine or any of the inactive ingredients in the product.
Side Effects
Common side effects of Citozar (Cytarabine) may include bone marrow suppression, nausea, vomiting, and hair loss. Regular monitoring of blood counts is crucial during treatment.
Usage Instructions
The dosage of Citozar (Cytarabine) is individualized based on the patient’s condition, weight, and response to treatment. It is administered intravenously by healthcare professionals experienced in cytotoxic drug administration.
Benefits Compared to Analogues
Cytarabine, when used in combination with other chemotherapeutic agents, has been shown to significantly improve outcomes in patients with leukemia. Clinical studies have demonstrated its efficacy in inducing remission, particularly in AML.
Suitable Patient Groups
Citozar (Cytarabine) is suitable for use in adult patients diagnosed with various forms of leukemia. Dosage adjustments may be necessary for specific patient populations, such as the elderly or those with renal impairment.
Storage and Shelf Life
Citozar (Cytarabine) should be stored according to the manufacturer’s instructions, typically at controlled room temperature. The shelf life of the product should be checked before use, and expired vials should not be used.
Packaging Description
Citozar (Cytarabine) is supplied as a powder for solution in a single-dose vial containing 1000 mg of the active ingredient. The packaging should be inspected for any signs of damage or tampering before use.
