Description
Closart (Losartan) Coated Tablets 100 mg. №30
Ingredients:
Each tablet contains 100 mg of losartan potassium as the active ingredient. Other ingredients include lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, and more.
Mechanism of Action:
Losartan, an angiotensin II receptor blocker (ARB), inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and decreased blood pressure.
Pharmacological Properties:
Losartan selectively blocks the angiotensin II receptor, resulting in vasodilation and reduced aldosterone secretion, thereby lowering blood pressure and improving cardiac function.
Indications for Use:
Closart tablets are indicated for the treatment of hypertension and for reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy.
Contraindications:
Avoid Closart if pregnant, have severe liver impairment, or allergic to losartan. It is contraindicated in patients with bilateral renal artery stenosis.
Side Effects:
Common side effects may include dizziness, fatigue, and hyperkalemia. Consult a healthcare provider for any adverse reactions.
Usage Instructions:
The usual starting dose is 50 mg once daily, which may be increased to 100 mg once daily based on blood pressure response. Take as prescribed, with or without food.
Benefits Compared to Analogues:
Closart, with its active ingredient losartan, has been shown in studies to effectively lower blood pressure and reduce the risk of cardiovascular events, offering a reliable treatment option for hypertension.
Suitable Patient Groups:
Closart can be used in various patient groups, including adults, elderly individuals, and those with hypertension and left ventricular hypertrophy.
Storage and Shelf Life:
Store Closart tablets in a cool, dry place away from moisture and sunlight. Check the expiration date on the packaging and do not use after the specified date.
Packaging Description:
Closart tablets are available in packs of 30 coated tablets, each containing 100 mg of losartan potassium.
Clinical Evidence and Proven Effectiveness:
Clinical studies have shown that losartan effectively reduces blood pressure and has a favorable safety profile. A study in the Journal of Hypertension demonstrated the efficacy of losartan in lowering blood pressure in patients with essential hypertension.
