Description

Co-Amlessa Tablets 8 mg/2.5 mg/10 mg

Ingredients:

• Perindopril tert-butylamine 8 mg
• Indapamide 2.5 mg
• Amlodipine 10 mg

Mechanism of Action:

Co-Amlessa tablets combine the actions of perindopril, indapamide, and amlodipine to achieve comprehensive blood pressure control. Perindopril is an ACE inhibitor, indapamide is a thiazide diuretic, and amlodipine is a calcium channel blocker. This combination targets multiple pathways involved in blood pressure regulation, resulting in synergistic effects.

Pharmacological Properties:

The pharmacological properties of Co-Amlessa stem from the individual actions of its components. Perindopril inhibits ACE, reducing angiotensin II levels. Indapamide promotes diuresis and vasodilation. Amlodipine blocks calcium channels, leading to vasodilation. Together, these actions result in decreased peripheral resistance and improved blood flow.

Indications for Use:

Co-Amlessa tablets are indicated for the treatment of hypertension in patients whose blood pressure is inadequately controlled on monotherapy with any of the individual components.

Contraindications:

Avoid Co-Amlessa if you have known allergies to any of the ingredients, a history of angioedema related to ACE inhibitors, or if you are pregnant. Consult a healthcare provider for alternative treatment options in these cases.

Side Effects:

Common side effects of Co-Amlessa may include dizziness, headache, and peripheral edema. These side effects are typically mild and transient. Monitor for any adverse reactions and report them to your healthcare provider promptly.

Usage Instructions:

Take one tablet of Co-Amlessa daily, preferably in the morning, with or without food. Swallow the tablet whole with a glass of water; do not crush or chew it.

Benefits Compared to Analogues:

Studies have demonstrated that the triple combination therapy in Co-Amlessa provides superior blood pressure control compared to individual components alone. The synergistic effects of perindopril, indapamide, and amlodipine offer enhanced efficacy in managing hypertension.

Suitable Patient Groups:

Co-Amlessa is suitable for adult patients with hypertension who require combination therapy for optimal blood pressure management. Dosage adjustments may be necessary for specific patient populations such as the elderly or those with renal impairment.

Storage and Shelf Life:

Store Co-Amlessa tablets in a cool, dry place away from direct sunlight. Check the packaging for the expiration date and do not use the product beyond that date.

Packaging Description:

Each pack of Co-Amlessa contains 30 tablets of the specified strength. The packaging is designed to maintain the integrity and stability of the tablets until the expiration date.