Description

Co-Amlessa Tablets

Composition:

• Perindopril tert-butylamine: 8 mg
• Indapamide: 2.5 mg
• Amlodipine: 5 mg

Mechanism of Action:

Co-Amlessa tablets combine perindopril, indapamide, and amlodipine to achieve effective blood pressure control in hypertensive patients. Perindopril is an ACE inhibitor, indapamide is a thiazide diuretic, and amlodipine is a calcium channel blocker. This combination targets multiple pathways involved in blood pressure regulation, leading to superior outcomes compared to individual therapies.

Pharmacological Properties:

The synergistic action of perindopril, indapamide, and amlodipine helps in reducing systolic and diastolic blood pressure by different mechanisms, including vasodilation, diuresis, and inhibition of the renin-angiotensin-aldosterone system.

Indications for Use:

Co-Amlessa tablets are indicated for the treatment of hypertension in patients whose blood pressure is inadequately controlled by monotherapy with individual components.

Contraindications:

Avoid using Co-Amlessa if you are allergic to any of the ingredients, have a history of angioedema related to previous ACE inhibitor therapy, or if you are pregnant.

Side Effects:

Common side effects may include dizziness, headache, edema, and cough. If you experience any severe or persistent side effects, contact your healthcare provider.

Usage Instructions:

Take one tablet daily, preferably in the morning, with or without food. Swallow the tablet whole with a glass of water; do not crush or chew it.

Benefits Compared to Analogues:

Studies have demonstrated that the triple combination therapy in Co-Amlessa tablets provides superior blood pressure control compared to dual combinations or monotherapy. The efficacy of Co-Amlessa in managing hypertension is well-established.

Suitable Patient Groups:

Co-Amlessa can be used in adult patients. Dosage adjustments may be necessary in individuals with liver or kidney impairment. Consult a healthcare professional for appropriate guidance.

Storage Conditions and Shelf Life:

Store Co-Amlessa tablets in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product beyond that date.

Packaging Description:

Each package contains 30 tablets of Co-Amlessa, with clear labeling of the active ingredients and dosage strength.

Clinical Evidence and Proven Effectiveness:

Studies have shown that the combination of perindopril, indapamide, and amlodipine in Co-Amlessa tablets effectively controls blood pressure in hypertensive patients. Research published in the Journal of Hypertension demonstrated a significant reduction in systolic and diastolic blood pressure with this triple combination therapy, highlighting its efficacy in managing hypertension.