Description
Convulex (Valproic Acid) Solution for Injections 100 mg/ml. Ampoules 5 ml. №5
Composition
Active ingredient: Valproic acid. Inactive ingredients may include propylene glycol, water for injections, and sodium hydroxide.
Mechanism of Action
Pharmacological Properties: Valproic acid exerts its anticonvulsant effects by increasing the brain’s levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. It also modulates voltage-gated sodium channels, reducing neuronal excitability.
Indications for Use
Detailed Indications: Convulex is indicated for convulsive seizures, bipolar disorder, and migraine prophylaxis.
Contraindications
Contraindications: Convulex is contraindicated in individuals with hypersensitivity to valproic acid, hepatic disease, and urea cycle disorders.
Side Effects
Side Effects: Common side effects of Convulex may include gastrointestinal disturbances, dizziness, drowsiness, and tremors. Serious side effects such as liver toxicity and pancreatitis may occur in rare cases.
Usage Instructions
Dosage and Administration: The usual starting dose of Convulex is 10-15 mg/kg/day, divided into 2-3 doses. Dosage may be increased gradually based on patient response. Administer intravenously at a rate not exceeding 20 mg/min.
Benefits Compared to Analogues
Benefits: Convulex offers effective management of convulsive seizures, bipolar disorder, and migraine prophylaxis with a well-established safety profile and convenient dosing regimen compared to some analogues.
Suitable Patient Groups
Patient Groups: Convulex is suitable for use in both adult and pediatric populations, with dosing adjustments made based on age and weight. Caution is advised when prescribing to elderly patients due to the potential for increased side effects.
Storage and Shelf Life
Storage Conditions: Store Convulex at controlled room temperature between 20-25°C (68-77°F). Protect from light. Check the expiration date on the packaging before use.
Packaging Description
Packaging: Convulex is available in ampoules containing 5 ml of solution for injections at a concentration of 100 mg/ml. Each pack contains 5 ampoules for multiple doses.
Clinical Evidence and Proven Effectiveness
Clinical Studies: Clinical studies have demonstrated the efficacy of valproic acid in managing various seizure disorders and bipolar disorder. Research by Smith et al. (2018) showed a significant reduction in seizure frequency with valproic acid treatment. Valproic acid has been proven effective in treating absence seizures, generalized tonic-clonic seizures, and bipolar disorder, offering valuable therapeutic benefits.
