Description
Corvitol-100 (Metoprolol) Tablets 100 mg. №50
Ingredients
Active ingredient: Metoprolol tartrate 100 mg per tablet.
Mechanism of Action
Metoprolol, the active ingredient in Corvitol-100, is a selective beta-blocker that antagonizes beta1-adrenergic receptors. By blocking the effects of catecholamines such as epinephrine, metoprolol reduces heart rate, myocardial contractility, and cardiac output. This results in decreased oxygen demand by the heart and lower blood pressure.
Pharmacological Properties
Corvitol-100 exhibits antianginal, antihypertensive, and antiarrhythmic properties. It selectively blocks beta1-adrenergic receptors in the heart, leading to reduced heart rate and contractility. Additionally, it inhibits renin release from the kidneys, contributing to its antihypertensive effects.
Indications for Use
Corvitol-100 is indicated for the treatment of hypertension, angina pectoris, and heart failure. It is commonly prescribed to manage high blood pressure, chest pain associated with angina, and to improve symptoms and reduce hospitalizations in heart failure patients.
Contraindications
Corvitol-100 should not be used in patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, or overt cardiac failure. Use caution in patients with bronchial asthma or chronic obstructive pulmonary disease (COPD), as beta-blockers may exacerbate bronchospasm.
Side Effects
Common side effects of Corvitol-100 include fatigue, dizziness, bradycardia, and gastrointestinal disturbances. Rare but serious side effects may include bronchospasm, heart block, and hypotension. Regular monitoring of heart rate and blood pressure is essential during treatment.
Usage Instructions
Take Corvitol-100 as directed by your healthcare provider. The usual starting dose is 100 mg once daily, with adjustments based on individual response. Swallow the tablet whole with a glass of water, preferably at the same time each day.
Benefits Compared to Analogues
Corvitol-100 offers the advantage of selective beta1-blockade, minimizing the risk of bronchospasm compared to non-selective beta-blockers. Its proven efficacy in reducing cardiovascular events and improving symptoms in various cardiovascular conditions sets it apart from other agents.
Suitable Patient Groups
Corvitol-100 is suitable for adult patients with hypertension, angina, or heart failure. Caution is advised when prescribing to elderly patients due to age-related changes in drug metabolism. Use in pediatric patients should be based on individual considerations and under pediatric cardiology supervision.
Storage and Shelf Life
Store Corvitol-100 at room temperature away from moisture and heat. Keep the tablets in the original packaging to protect from light. Check the expiration date on the packaging and do not use the product beyond this date.
Packaging Description
Corvitol-100 tablets are packaged in blister packs of 50 tablets each. The packaging is designed to maintain the integrity of the tablets and protect them from environmental factors that may affect their stability.
Clinical Evidence and Proven Effectiveness
Corvitol-100 (Metoprolol) has been extensively studied in clinical trials. Research published in the Journal of the American College of Cardiology demonstrated the efficacy of metoprolol in reducing cardiovascular events in hypertensive patients. The drug’s beta-blocking properties contribute to its effectiveness in managing hypertension, angina, and heart failure.
