Description
Denipim (Cefepime) Powder for Solution for Injections 1000 mg. №1 Vial
Ingredients
Active Ingredient: Cefepime. Inactive ingredients may include lactose.
Mechanism of Action
Pharmacological Properties: Cefepime, a fourth-generation cephalosporin, exhibits broad-spectrum bactericidal activity against various Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis.
Indications for Use
Indications: Denipim is indicated for the treatment of moderate to severe infections caused by susceptible bacteria.
Contraindications
Contraindications: Denipim should not be used in individuals with a known allergy to cefepime or other cephalosporins.
Side Effects
Side Effects: Common side effects of Denipim may include nausea, vomiting, diarrhea, and rash. Serious side effects such as severe allergic reactions are rare but should be reported to a healthcare provider immediately.
Usage Instructions
Administration: Denipim is administered via intravenous infusion over a 30-minute period. The dosage for adults typically ranges from 1 to 2 grams every 12 hours, with adjustments based on the infection’s severity.
Benefits Compared to Analogues
Benefits: Denipim offers the advantage of broad-spectrum antibacterial activity against a wide range of pathogens compared to earlier cephalosporins. Its efficacy in treating various infections has been well-documented in clinical studies.
Suitable Patient Groups
Patient Groups: Denipim is suitable for use in adult patients, including the elderly, who require treatment for moderate to severe bacterial infections. Dosage adjustments may be necessary for individuals with renal impairment.
Storage and Shelf Life
Storage: Denipim vials should be stored at room temperature, protected from light and moisture, to maintain stability. Adhere to the recommended storage conditions to preserve the product’s integrity.
Packaging Description
Packaging: Each Denipim vial contains 1000 mg of cefepime powder for reconstitution. The vial is designed for single-use and should be discarded appropriately after administration.
Clinical Evidence and Proven Effectiveness
Pharmacological Effects: Cefepime, the active component of Denipim, has demonstrated efficacy in clinical trials for treating various infections due to its potent bactericidal action against a broad spectrum of bacteria.
Clinical Studies: Clinical trials have shown that cefepime is effective in managing infections such as pneumonia, urinary tract infections, and intra-abdominal infections. Notably, a study in the Journal of Antimicrobial Chemotherapy highlighted cefepime’s effectiveness in treating febrile neutropenia in cancer patients.
Additional Information
Precautions: Patients with renal impairment should use Denipim with caution, as dosage adjustments may be necessary to prevent adverse effects.
- Discuss the risks and benefits of Denipim with your healthcare provider before initiating treatment.
- Report any allergic reactions or severe side effects to your healthcare provider promptly for appropriate management.
