Description
Dexametazon (Dexamethasone) Solution for Injections 4 mg/ml. 1ml. Ampoules №10
Ingredients:
Dexametazon solution for injections contains dexamethasone as the active ingredient.
Mechanism of Action:
Dexamethasone, a synthetic corticosteroid, exerts its pharmacological effects by binding to specific cytoplasmic receptors. This complex then enters the cell nucleus, modulating the transcription of various genes involved in inflammatory and immune responses.
Pharmacological Properties:
Dexamethasone possesses potent anti-inflammatory, immunosuppressant, and anti-allergic properties. It inhibits the production of inflammatory mediators, suppresses immune reactions, and reduces tissue edema.
Indications for Use:
Dexametazon is indicated for the treatment of allergic disorders, dermatological conditions, rheumatic diseases, respiratory disorders, certain neoplastic conditions, and autoimmune disorders.
Contraindications:
Avoid using Dexametazon in patients with systemic fungal infections or known hypersensitivity to dexamethasone. Prior consultation with a healthcare provider is crucial before initiating therapy.
Side Effects:
Common side effects of dexamethasone therapy include fluid retention, hypertension, mood changes, hyperglycemia, and gastrointestinal disturbances. Prolonged use may lead to adrenal suppression and increased susceptibility to infections.
Usage Instructions:
The recommended dosage of Dexametazon for adults typically ranges from 4 to 20 mg per day, depending on the underlying condition. Administration should be via intramuscular or intravenous routes under healthcare professional supervision.
Benefits Compared to Analogues:
Compared to other corticosteroids, dexamethasone exhibits higher anti-inflammatory potency and lower mineralocorticoid effects, making it a preferred choice in certain clinical scenarios.
Suitable Patient Groups:
Dexametazon can be used in pediatric and geriatric populations under appropriate medical guidance. Dosing adjustments may be necessary in these patient groups due to variations in drug metabolism and susceptibility to adverse effects.
Storage Conditions and Shelf Life:
Store Dexametazon at controlled room temperature away from light and moisture. Check the product packaging for specific storage instructions. The shelf life of the medication is typically mentioned on the packaging and should be adhered to.
Packaging Description:
The product is available in ampoules containing 1ml of Dexametazon solution for injections at a concentration of 4 mg/ml. Each package contains 10 ampoules for multiple doses.
Clinical Evidence and Proven Effectiveness:
Dexamethasone, the active component of Dexametazon, has been extensively researched for its anti-inflammatory and immunomodulatory effects. Notably, studies such as the RECOVERY trial have demonstrated the efficacy of dexamethasone in reducing mortality among critically ill COVID-19 patients by mitigating the cytokine storm associated with the disease.
