Description
Dibizid-M (Metformin Hydrochloride and Glipizide) Tablets
Composition
Dibizid-M tablets contain metformin hydrochloride and glipizide as active ingredients.
Mechanism of Action
Dibizid-M exerts its pharmacological effects by combining the actions of metformin and glipizide. Metformin works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. Glipizide stimulates the release of insulin from pancreatic beta cells. Together, they help to lower blood glucose levels and improve glycemic control in patients with type 2 diabetes mellitus.
Pharmacological Properties
The synergistic action of metformin and glipizide in Dibizid-M tablets enhances insulin sensitivity, reduces hepatic glucose production, and promotes glucose utilization in peripheral tissues. This combination helps to regulate blood sugar levels effectively.
Indications for Use
Dibizid-M tablets are indicated for the management of type 2 diabetes mellitus to improve glycemic control in adult patients.
Contraindications
Avoid using Dibizid-M tablets if you have a history of allergic reactions to metformin or glipizide, severe renal impairment, metabolic acidosis, or are in a state of diabetic ketoacidosis.
Side Effects
Common side effects of Dibizid-M may include gastrointestinal disturbances, such as nausea, vomiting, or diarrhea. Hypoglycemia may occur, especially when used in combination with other antidiabetic medications.
Usage Instructions
Take Dibizid-M tablets as prescribed by your healthcare provider. The typical recommended dose is determined based on individual needs and is usually taken orally with food to minimize gastrointestinal discomfort.
Benefits Compared to Analogues
Dibizid-M offers the advantage of combining the complementary mechanisms of metformin and glipizide in a single tablet, providing synergistic effects for improved glycemic control compared to using each medication alone.
Suitable Patient Groups
Dibizid-M is suitable for adult patients with type 2 diabetes mellitus. Dosage adjustments may be necessary for elderly individuals or those with renal impairment based on individual health status.
Storage and Shelf Life
Store Dibizid-M tablets in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the tablets beyond the specified shelf life.
Packaging Description
Dibizid-M tablets are typically available in packs of 60 tablets. Each tablet is film-coated for ease of swallowing and protection from moisture.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated the efficacy of Dibizid-M in lowering blood glucose levels and improving glycemic control in patients with type 2 diabetes mellitus. Clinical trials have shown that the combination of metformin and glipizide in Dibizid-M tablets leads to better outcomes compared to monotherapy with either drug.
