Description
Difors 80 (Amlodipine Besilate and Valsartan) Coated Tablets 5 mg/80 mg. №10
Composition
Each tablet contains 5 mg of amlodipine besilate and 80 mg of valsartan.
Mechanism of Action
Difors 80 works by relaxing blood vessels (amlodipine) and blocking angiotensin II (valsartan), resulting in vasodilation and decreased blood pressure.
Pharmacological Properties
The combination of amlodipine and valsartan in Difors 80 acts synergistically to lower blood pressure by different mechanisms, providing enhanced antihypertensive effects.
Indications for Use
Difors 80 is indicated for the treatment of hypertension to effectively lower blood pressure levels in adult patients.
Contraindications
Avoid using Difors 80 if pregnant, have severe liver impairment, or known hypersensitivity to amlodipine or valsartan.
Side Effects
Common side effects may include dizziness, headache, edema, and flushing. Contact your healthcare provider if you experience any persistent or severe adverse reactions.
Usage Instructions
The recommended dosage is one tablet daily, with or without food, swallowed whole with water. Follow the instructions of your healthcare provider for optimal results.
Benefits Compared to Analogues
Difors 80 offers the advantage of combining two distinct classes of antihypertensive agents, providing a comprehensive and effective approach to blood pressure management compared to single-agent therapies.
Suitable Patient Groups
Difors 80 is suitable for adult patients with hypertension. Special caution and dosage adjustments may be necessary for elderly individuals or those with specific medical conditions; consult a healthcare professional for personalized recommendations.
Storage and Shelf Life
Store Difors 80 in a cool, dry place away from direct sunlight. Keep the tablets in the original packaging and out of reach of children. Check the expiration date on the package and do not use expired medication.
Packaging Description
Difors 80 is available in blister packs containing 10 coated tablets. Each pack is labeled with the product name, dosage strength, and other relevant information for easy identification.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated that the combination of amlodipine and valsartan in Difors 80 provides a synergistic effect in lowering blood pressure. A meta-analysis published in the Journal of Hypertension highlighted the superior efficacy of this combination therapy compared to monotherapy with either drug alone.
