Description
Duglimax (Metformin Hydrochloride) Tablets 500 mg/1 mg. №30
Ingredients
Active ingredient: Metformin hydrochloride
Mechanism of Action
Metformin hydrochloride works by decreasing glucose production in the liver and improving insulin sensitivity in the muscles. This dual mechanism helps lower blood sugar levels and improve overall glycemic control in patients with type 2 diabetes mellitus.
Pharmacological Properties
Duglimax, containing metformin hydrochloride, belongs to the biguanide class of oral antidiabetic agents. It reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Indications for Use
Indicated for: Duglimax is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Contraindications
Contraindications: Duglimax is contraindicated in patients with renal impairment, severe infections, or metabolic acidosis. It should not be used in individuals with hypersensitivity to metformin.
Side Effects
Common side effects of Duglimax may include gastrointestinal disturbances such as diarrhea, nausea, and abdominal discomfort. In rare cases, lactic acidosis may occur, especially in patients with predisposing factors.
Usage Instructions
Dosage: The usual starting dose of Duglimax is 500 mg or 850 mg once daily, with meals or as directed by a healthcare provider. Tablets should be swallowed whole with a full glass of water to reduce the risk of gastrointestinal side effects.
Benefits Compared to Analogues
Duglimax, with metformin hydrochloride as its active ingredient, offers proven efficacy in improving glycemic control with a low risk of hypoglycemia compared to some other antidiabetic agents. It is considered a first-line therapy due to its well-established benefits and safety profile.
Suitable Patient Groups
Duglimax is suitable for adult patients with type 2 diabetes mellitus who require pharmacological intervention to manage their condition. It is generally well-tolerated and can be used in a wide range of patient populations, including the elderly and individuals with comorbidities.
Storage and Shelf Life
Duglimax tablets should be stored at room temperature away from moisture and heat. The shelf life of the product is typically mentioned on the packaging and should be checked before use.
Packaging Description
Duglimax is available in blister packs containing 30 tablets of 500 mg/1 mg strength. The packaging is designed to protect the tablets from external factors and maintain their stability until consumption.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated the efficacy of metformin in improving glycemic control and reducing hemoglobin A1c levels in patients with type 2 diabetes mellitus. Clinical trials have shown that Duglimax can lead to better long-term outcomes and is associated with cardiovascular benefits and potential weight management effects.
