Description
Enap HL (Enalapril Maleate and Hydrochlorothiazide) Tablets 20 mg/12.5 mg. №20
Composition
- Enalapril maleate – 20 mg
- Hydrochlorothiazide – 12.5 mg
Mechanism of Action
Pharmacological Properties: Enalapril inhibits the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide, a thiazide diuretic, promotes diuresis and helps lower blood pressure.
Indications for Use
Enap HL is indicated for the treatment of hypertension when control is not achieved with enalapril alone.
Contraindications
Do not use Enap HL if you are allergic to any of the ingredients, pregnant, have severe renal impairment, or are breastfeeding.
Side Effects
Common side effects may include dizziness or lightheadedness, especially during the initial days of treatment. Caution is advised when driving or operating machinery.
Usage Instructions
Dosage: The usual dose for adults is one tablet once daily. Dosage adjustments may be made by your healthcare provider based on your condition.
Directions: Take Enap HL exactly as prescribed, swallowing the tablet whole with a glass of water.
Benefits Compared to Analogues
Enap HL offers enhanced efficacy in blood pressure control compared to enalapril alone, as demonstrated in clinical studies.
Suitable Patient Groups
Enap HL is suitable for adult patients with hypertension that is not adequately controlled with enalapril monotherapy.
Storage and Shelf Life
Store Enap HL in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use if expired.
Packaging Description
Enap HL is available in blister packs containing 20 tablets of 20 mg enalapril maleate and 12.5 mg hydrochlorothiazide each.
Clinical Evidence and Proven Effectiveness
Studies have shown that the combination of enalapril and hydrochlorothiazide in Enap HL effectively lowers blood pressure in hypertensive patients. Research published in the Journal of Hypertension highlighted the superior efficacy of this combination therapy over enalapril monotherapy.
A randomized controlled trial published in the New England Journal of Medicine compared the efficacy of enalapril alone versus the combination of enalapril and hydrochlorothiazide. The study concluded that the combination therapy resulted in better blood pressure control and reduced cardiovascular events.