Description
Fluconazol (Fluconazole) Forte Capsules 200 mg. №2
Ingredients:
Each capsule contains 200 mg of fluconazole.
Mechanism of Action:
Fluconazole, the active ingredient in Fluconazol forte capsules, is a triazole antifungal agent. It acts by inhibiting the enzyme lanosterol 14α-demethylase, which is essential for the synthesis of ergosterol in fungal cell membranes. This disruption leads to increased membrane permeability and ultimately cell death.
Pharmacological Properties:
Fluconazole exhibits fungistatic activity against a wide range of pathogenic fungi, including Candida species, Cryptococcus neoformans, and dermatophytes. It is well-absorbed orally and distributed extensively in body tissues, reaching therapeutic concentrations in the cerebrospinal fluid.
Indications for Use:
Fluconazol forte capsules are indicated for the treatment of various fungal infections, such as vaginal candidiasis, oropharyngeal and esophageal candidiasis, cryptococcal meningitis, and other systemic fungal infections. It is also used for the prophylaxis of fungal infections in immunocompromised patients.
Contraindications:
Do not take Fluconazol forte capsules if you have a known hypersensitivity to fluconazole or other azole antifungals. Caution is advised in patients with hepatic impairment and concomitant use of certain medications metabolized by the CYP3A4 pathway.
Side Effects:
Common side effects of fluconazole may include gastrointestinal disturbances, headache, rash, and elevated liver enzymes. Rare but serious adverse effects include hepatotoxicity, anaphylaxis, and severe skin reactions. Patients should seek medical attention if they experience any unusual symptoms.
Usage Instructions:
The recommended dosage of Fluconazol forte capsules is one 200 mg capsule taken orally once daily, with or without food. Dosage adjustments may be necessary in patients with renal impairment. The capsules should be swallowed whole with a full glass of water.
Benefits Compared to Analogues:
Fluconazole offers several advantages over other antifungal agents, including broad-spectrum activity against various fungal species, high bioavailability, and minimal drug interactions. Its once-daily dosing regimen enhances patient adherence and convenience, leading to improved treatment outcomes.
Suitable Patient Groups:
Fluconazol forte capsules are suitable for use in adults, adolescents, and children for the treatment of fungal infections. Dosing adjustments may be required in elderly patients and those with renal impairment. Pregnant and lactating women should consult their healthcare provider before using fluconazole.
Storage and Shelf Life:
Store Fluconazol forte capsules at room temperature away from moisture and heat. Keep the capsules in their original packaging to protect them from light. Check the expiration date on the package and do not use expired medication.
Packaging Description:
Each package of Fluconazol forte capsules contains 2 capsules of 200 mg strength. The capsules are sealed in blister packs to ensure product integrity and are labeled with dosage information and expiration date.
Clinical Evidence and Proven Effectiveness:
Fluconazole has been extensively studied in clinical trials, demonstrating its efficacy in the treatment of various fungal infections. Research published in reputable medical journals has shown that fluconazole is highly effective in eradicating fungal pathogens, with favorable safety profiles and low rates of resistance development.
