Description
Gliucofaj XR Tablets with Prolonged Release 1000 mg. №30
Ingredients
Each tablet contains 1000 mg of Metformin Hydrochloride.
Mechanism of Action
Metformin works by decreasing hepatic glucose production and increasing peripheral glucose uptake, improving insulin sensitivity.
Pharmacological Properties
Metformin is a biguanide that reduces hyperglycemia without increasing insulin secretion. It also has beneficial effects on lipid metabolism.
Indications for Use
Gliucofaj XR tablets are indicated for the treatment of type 2 diabetes mellitus to improve glycemic control.
Contraindications
Avoid using Gliucofaj XR tablets in patients with severe renal impairment, metabolic acidosis, or hypersensitivity to metformin. Assess renal function before initiation.
Side Effects
Common side effects may include gastrointestinal disturbances like nausea, vomiting, and diarrhea. Lactic acidosis is a rare but serious adverse effect.
Usage Instructions
The recommended dose is one tablet daily with food to reduce gastrointestinal side effects. Swallow the tablet whole with a full glass of water.
Benefits Compared to Analogues
Gliucofaj XR offers the advantage of prolonged release, leading to reduced gastrointestinal side effects and improved patient compliance compared to immediate-release formulations.
Suitable Patient Groups
Gliucofaj XR can be used in adults with type 2 diabetes. Dosage adjustments may be necessary in elderly patients or those with hepatic impairment.
Storage and Shelf Life
Store Gliucofaj XR tablets in a cool, dry place below 25°C. Protect from moisture. The shelf life is as indicated on the packaging.
Packaging Description
Gliucofaj XR tablets are available in packs of 30 tablets. Each tablet is film-coated for ease of swallowing.
Scientific Evidence
Research supports the efficacy of metformin in type 2 diabetes management by improving insulin sensitivity and reducing hepatic glucose output. Clinical studies have demonstrated the benefits of extended-release formulations in minimizing gastrointestinal side effects and enhancing treatment adherence.
