Description
Itracon capsules 100 mg. №6
Ingredients
Each capsule contains 100 mg of Itraconazole.
Mechanism of Action
Itraconazole, a triazole antifungal agent, exerts its therapeutic effects by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately cell death in susceptible fungi.
Pharmacological Properties
Itraconazole demonstrates broad-spectrum activity against various fungal pathogens, including Aspergillus, Blastomyces, and Histoplasma species. Its fungistatic action prevents the growth and proliferation of fungi, aiding in the resolution of infections.
Indications for Use
Itracon capsules are indicated for the treatment of fungal infections, such as aspergillosis, blastomycosis, and histoplasmosis. It is recommended for patients with confirmed fungal infections requiring systemic therapy.
Contraindications
Do not use Itracon capsules if you have a known hypersensitivity to Itraconazole or other azole antifungals. Additionally, individuals with pre-existing liver disease should avoid this medication due to the risk of hepatotoxicity. Consult your healthcare provider before initiating treatment.
Side Effects
- Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
- Headache
- Rash
- Elevations in liver enzymes
Usage Instructions
The typical dosage regimen involves taking 100-200 mg of Itraconazole once daily. Swallow the capsules whole with a full glass of water, preferably with a meal to enhance absorption. Adherence to the prescribed dosing schedule is crucial for optimal therapeutic outcomes.
Benefits Compared to Analogues
Compared to other antifungal agents, Itraconazole offers the advantage of broad-spectrum activity against a diverse range of fungal species. Its once-daily dosing regimen enhances convenience and patient compliance, particularly in the management of chronic fungal infections.
Suitable Patient Groups
Itraconazole can be used in pediatric and adult populations for the treatment of fungal infections. However, caution is advised in elderly patients and those with hepatic impairment, as dosage adjustments may be necessary based on individual factors.
Storage and Shelf Life
Store Itracon capsules in a cool, dry place away from direct sunlight. Ensure proper sealing of the packaging to prevent moisture ingress. Check the expiration date on the packaging and discard any expired medication appropriately.
Packaging Description
Itracon capsules are typically supplied in blister packs containing 6 capsules per pack. The packaging should include essential information such as the drug name, strength, dosage instructions, and manufacturer details for patient reference.
Clinical Evidence and Proven Effectiveness
Itraconazole has been the subject of numerous clinical studies evaluating its efficacy in the treatment of fungal infections. Clinical trials have demonstrated the superior antifungal activity of Itraconazole, particularly in cases of invasive fungal diseases and refractory infections. Its favorable safety profile and established effectiveness make it a cornerstone in antifungal therapy.
