Description
L-cet (levocetirizine dihydrochloride) Syrup 2.5 mg/5 ml – 60 ml Vial
Ingredients
Active Ingredient: Levocetirizine dihydrochloride. Other ingredients may include sucrose, glycerol, propylene glycol, sodium acetate, and purified water.
Mechanism of Action
Levocetirizine dihydrochloride, the active enantiomer of cetirizine, exerts its pharmacological effects by selectively antagonizing histamine H1 receptors. This action leads to the inhibition of histamine-mediated allergic responses.
Pharmacological Properties
Levocetirizine demonstrates superior efficacy and safety compared to racemic cetirizine due to its higher selectivity for histamine H1 receptors. It has a rapid onset of action and a prolonged duration of effect.
Indications for Use
Indicated for: Relief of symptoms associated with allergic rhinitis, such as sneezing, runny nose, and itching.
Contraindications
Do not use if: Hypersensitive to levocetirizine or any component of the formulation. Contraindicated in patients with severe renal impairment.
Side Effects
Common side effects: May include drowsiness, headache, and dry mouth. Patients should consult a healthcare professional if these effects persist or worsen.
Usage Instructions
Dosage: Adults and children over 6 years: 5 ml once daily. Children 2-6 years: 2.5 ml once daily. Dosage should be determined by a healthcare provider.
Directions for use: Shake well before use. Do not exceed the recommended dose.
Benefits Compared to Analogues
Levocetirizine has shown enhanced efficacy and safety profiles compared to racemic cetirizine, making it a preferred choice for managing allergic conditions.
Suitable Patient Groups
Levocetirizine is suitable for adults and children over 2 years of age. Dosage adjustments may be necessary based on individual patient characteristics.
Storage and Shelf Life
- Storage: Store at room temperature away from light and moisture.
- Shelf Life: Refer to the expiration date on the packaging.
Packaging Description
The product is available in a 60 ml vial containing levocetirizine dihydrochloride syrup with a concentration of 2.5 mg/5 ml.
Clinical Evidence and Proven Effectiveness
Levocetirizine dihydrochloride is supported by clinical trials demonstrating its effectiveness in alleviating symptoms of allergic rhinitis and chronic idiopathic urticaria. Its pharmacological properties offer rapid relief and sustained control of allergic manifestations.
