Description
Metoclopramid (Metoclopramide) Ampoules 5 mg/ml. 2 ml. №10
Ingredients
- Active ingredient: Metoclopramide 5 mg/ml
- Other ingredients: sodium chloride, water for injections
Dosage
Dosage: The usual adult dose is 10-15 mg (2-3 ampoules) per day, divided into 2-3 doses.
Indications
Indications: Metoclopramide is indicated for the treatment of nausea, vomiting, and symptoms of gastroparesis.
Contraindications
Contraindications: Do not use in patients with pheochromocytoma, gastrointestinal hemorrhage, or a history of seizures.
Directions
Directions: Administer by intramuscular or intravenous injection. Do not exceed the recommended dose.
Scientific Evidence
Metoclopramide works by blocking dopamine receptors in the chemoreceptor trigger zone, which helps to reduce nausea and vomiting. Studies have shown that metoclopramide is effective in managing symptoms of gastroparesis and improving gastric emptying.
Additional Information
Metoclopramide has prokinetic and antiemetic properties, making it a first-line treatment for gastroparesis. It is generally well-tolerated, but long-term use may lead to side effects like tardive dyskinesia.
Pharmacological Effects: Metoclopramide acts as a dopamine antagonist, stimulating gastrointestinal motility and enhancing gastric emptying. It also has antiemetic properties by blocking dopamine receptors in the chemoreceptor trigger zone.
Clinical Trials: Research has shown the efficacy of metoclopramide in improving symptoms of gastroparesis, including enhanced gastric emptying and reduced nausea and vomiting compared to placebo.
