Description
Metronidazol (Metronidazole) Solution for Infusions 0.5% 100 ml
Ingredients
- Active ingredient: Metronidazole
- Inactive ingredients may include sodium chloride, citric acid, and water for injection
Dosage
- Dosage: The usual dose is 500 mg infused over 1 hour every 8 hours
- Dosage may vary based on the condition being treated
Indications
- Indications: Metronidazole is indicated for the treatment of various infections caused by susceptible anaerobic bacteria and parasites
Contraindications
- Contraindications: Do not use in patients with a history of hypersensitivity to metronidazole or other nitroimidazole derivatives
Directions
- Administration: Administer by intravenous infusion only
- Follow the instructions provided by your healthcare provider
Scientific Evidence
Metronidazole exerts its antimicrobial effects by disrupting DNA and protein synthesis in susceptible organisms. Studies have shown its efficacy in treating infections such as bacterial vaginosis, trichomoniasis, and certain anaerobic bacterial infections.
Additional Information
- Metronidazole has been extensively studied and is considered a first-line treatment for many anaerobic infections
- Clinical trials have demonstrated its effectiveness in various clinical settings, including gynecological and gastrointestinal infections
Pharmacological Effects: Metronidazole enters bacterial and protozoal cells where it is reduced by microbial enzymes to an active form. This leads to DNA damage and cell death, effectively treating the infection.
Comparative Effectiveness: Metronidazole is comparable in efficacy to other antibiotics like clindamycin and tinidazole in treating anaerobic infections. However, its broad spectrum of activity and low cost make it a preferred choice in many clinical scenarios.
