Description

Septipim (Cefepime) Powder for Solution for Injections 1000 mg

Ingredients

• Active Ingredient: Cefepime
• Inactive ingredients may include lactose, sodium carbonate, or other excipients

Dosage

• Dosage: The usual adult dose is 1 to 2 grams every 12 hours, depending on the severity of the infection
• Dosage adjustments may be necessary in patients with renal impairment

Indications

• Indications: Septicemia, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, skin and skin structure infections, and gynecological infections

Contraindications

• Contraindications: Hypersensitivity to cefepime or other cephalosporins

Directions

• Administration: Administer by intravenous infusion over 30 minutes
• Follow reconstitution and dilution instructions carefully

Scientific Evidence

Cefepime, the active ingredient in Septipim, is a fourth-generation cephalosporin with broad-spectrum antibacterial activity. Studies have shown its efficacy in treating various infections, including those caused by multidrug-resistant pathogens. Research by Livermore et al. (2002) demonstrated the potency of cefepime against extended-spectrum beta-lactamase-producing bacteria.

Additional Information

• It is important to monitor renal function during cefepime therapy, especially in elderly patients
• Adverse effects may include diarrhea, nausea, and hypersensitivity reactions

Cefepime exerts its pharmacological action by inhibiting bacterial cell wall synthesis, leading to cell death. Its extended spectrum of activity covers a wide range of Gram-positive and Gram-negative bacteria, making it a valuable option in the treatment of severe infections.

Comparative studies have shown cefepime to be as effective as other broad-spectrum antibiotics with a lower risk of resistance development. Its ability to penetrate tissues and maintain high concentrations at the infection site contributes to its clinical efficacy.