Description
Siofor 850 (Metformin Hydrochloride) Coated Tablets 850 mg. №60
Ingredients
- Active ingredient: Metformin hydrochloride 850 mg.
Dosage
- Dosage: The usual starting dose is 500 mg or 850 mg once daily with meals. Dosage can be adjusted based on blood glucose levels.
Indications
- Indications: Siofor 850 is indicated for the treatment of type 2 diabetes mellitus in adults, particularly in overweight patients.
Contraindications
- Contraindications: Do not use in patients with severe renal impairment, metabolic acidosis, or hypersensitivity to metformin.
Directions
- Directions: Swallow the tablets whole with a glass of water during or after meals to reduce gastrointestinal side effects.
Scientific Evidence
- Metformin’s efficacy: Metformin, the active ingredient in Siofor 850, is a first-line medication for type 2 diabetes due to its proven efficacy in lowering blood glucose levels and improving insulin sensitivity.
- Pharmacological effects: Metformin works by decreasing glucose production in the liver, increasing glucose uptake in muscles, and improving insulin utilization, leading to better blood sugar control.
Additional Information
- Clinical trials: Clinical studies have shown that metformin not only lowers blood sugar levels but also reduces the risk of cardiovascular complications in diabetic patients.
- Comparative effectiveness: Compared to other oral antidiabetic drugs, metformin has a lower risk of hypoglycemia and weight gain, making it a preferred choice for many healthcare providers.
