Description
Avelox (Moxifloxacin) Solution for Infusions 400 mg. 250 ml. №1
Composition
Active Ingredient: Moxifloxacin
Other Ingredients: Sodium chloride, hydrochloric acid, sodium hydroxide, and water for injections.
Mechanism of Action
Moxifloxacin, a fluoroquinolone antibiotic, exerts its bactericidal action by inhibiting DNA gyrase and topoisomerase IV enzymes, essential for bacterial DNA replication and repair.
Pharmacological Properties
Moxifloxacin demonstrates broad-spectrum antibacterial activity against susceptible pathogens. It penetrates well into various tissues and exhibits concentration-dependent killing.
Indications for Use
Indicated for: Treatment of infections caused by susceptible bacteria, including respiratory tract infections, skin and soft tissue infections, and intra-abdominal infections.
Contraindications
Do not use Avelox if: You have a history of hypersensitivity to moxifloxacin or other quinolones. Avoid use if there is a history of tendon disorders related to fluoroquinolone use.
Side Effects
Common side effects may include gastrointestinal disturbances, headache, and dizziness. Rare but serious adverse effects include tendon rupture, peripheral neuropathy, and central nervous system effects.
Usage Instructions
Administration: Avelox should be administered by intravenous infusion over 60 minutes. Do not mix with other medications in the same infusion.
Dosage: The typical dose is 400 mg once daily. Treatment duration varies based on the infection’s type and severity.
Benefits Compared to Analogues
Avelox offers the advantage of once-daily dosing, making it convenient for patients and potentially improving adherence to therapy. Its broad spectrum of activity against various pathogens contributes to its efficacy.
Suitable Patient Groups
Avelox is suitable for adults of all ages, including the elderly, who require intravenous antibiotic therapy for susceptible bacterial infections. It is not recommended for use in children due to potential safety concerns.
Storage and Shelf Life
Storage: Keep the solution for infusion at controlled room temperature between 20°C to 25°C (68°F to 77°F). Protect from light and moisture.
Shelf Life: Check the expiration date on the packaging. Do not use if expired.
Packaging Description
Avelox solution for infusions is supplied in a 250 ml container with a concentration of 400 mg per unit. Each package contains one unit for single use.
Clinical Evidence and Proven Effectiveness
Clinical studies have shown the efficacy of Avelox in treating various bacterial infections with a favorable safety profile. For instance, in a study by Patel et al., Avelox demonstrated high efficacy in the management of community-acquired pneumonia.
