Description
Azapin (Clozapine) Tablets 0.025 g. №50
Composition
Active ingredient: Clozapine 0.025 g per tablet.
Mechanism of Action
Clozapine exerts its pharmacological effects by antagonizing dopamine receptors in the brain, leading to improved symptoms of schizophrenia. It also affects serotonin, histamine, and muscarinic receptors, contributing to its unique mechanism of action.
Pharmacological Properties
Clozapine, the primary component of Azapin tablets, demonstrates efficacy in treating treatment-resistant schizophrenia by modulating various neurotransmitter receptors.
Indications for Use
Azapin tablets are indicated for the treatment of severe schizophrenia in patients who have not responded to other antipsychotic medications.
Contraindications
Azapin should not be used in individuals with a history of agranulocytosis or severe neutropenia due to the associated risks.
Side Effects
Common side effects of Azapin may include drowsiness, dizziness, weight gain, and constipation. Serious side effects such as agranulocytosis and seizures may occur, requiring immediate medical attention.
Usage Instructions
Patients should take Azapin tablets orally as prescribed by their healthcare provider. The usual starting dose is 12.5 mg once or twice daily, with gradual titration based on individual response and tolerability.
Benefits Compared to Analogues
Clozapine has shown superior efficacy in reducing symptoms and improving the quality of life in patients with refractory schizophrenia compared to other antipsychotic medications.
Suitable Patient Groups
Azapin can be prescribed to adult patients with severe schizophrenia who have not responded to conventional antipsychotic treatments. It is not recommended for children or elderly individuals due to safety concerns.
Storage and Shelf Life
Store Azapin tablets in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product after the specified shelf life has passed.
Packaging Description
Azapin tablets are available in a package containing 50 tablets, each with a dosage of 0.025 g of Clozapine.
Clinical Evidence and Proven Effectiveness
Clinical studies have shown that clozapine is effective in managing treatment-resistant schizophrenia, with research indicating its superiority in symptom reduction and quality of life improvement compared to other antipsychotic medications (Meltzer et al., 2012). Additionally, clozapine has demonstrated a reduction in the risk of suicide among patients with schizophrenia, emphasizing its crucial role in severe mental health conditions (Tiihonen et al., 2006).
