Description
Azitromicin (Azithromycin) Capsules 500 mg. N3
Ingredients
Each capsule contains 500 mg of azithromycin.
Mechanism of Action
Azitromicin (azithromycin) is a macrolide antibiotic that exerts its bacteriostatic effect by binding to the 50S ribosomal subunit of susceptible bacteria. By inhibiting protein synthesis, azithromycin prevents bacterial growth and reproduction.
Pharmacological Properties
Azitromicin demonstrates a broad spectrum of activity against various Gram-positive, Gram-negative, atypical, and anaerobic bacteria. It is well-absorbed orally and distributed throughout the body, reaching high concentrations in tissues.
Indications for Use
Azitromicin capsules are indicated for the treatment of bacterial infections caused by susceptible microorganisms, including respiratory tract infections, skin and soft tissue infections, sexually transmitted diseases, and others.
Contraindications
Azitromicin should not be used in individuals with a known hypersensitivity to azithromycin, macrolide antibiotics, or any component of the formulation. Caution is advised in patients with a history of cholestatic jaundice or hepatic dysfunction associated with prior azithromycin use.
Side Effects
The common side effects of azitromicin may include gastrointestinal disturbances, such as nausea, vomiting, diarrhea, and abdominal pain. Rare but serious side effects may include hepatotoxicity, allergic reactions, and QT interval prolongation.
Usage Instructions
The usual dosage of azitromicin is one capsule (500 mg) taken orally once daily for the prescribed duration of therapy. The capsules should be swallowed whole with a full glass of water, with or without food.
Benefits Compared to Analogues
Azitromicin offers the advantage of a convenient once-daily dosing regimen and a broad spectrum of activity against various pathogens, making it a preferred choice in the treatment of respiratory and skin infections.
Suitable Patient Groups
Azitromicin is generally well-tolerated across different age groups, including children and elderly patients. However, dosage adjustments may be necessary in individuals with renal impairment to prevent drug accumulation.
Storage and Shelf Life
- Azitromicin capsules should be stored at room temperature (15-30°C) in a dry place away from moisture and light.
- Keep the medication out of reach of children and pets.
- Do not use azitromicin after the expiration date printed on the packaging.
Packaging Description
Azitromicin capsules are typically supplied in blister packs or HDPE bottles containing a specific number of capsules per pack. The packaging is designed to ensure product integrity and protection from external factors.
Clinical Evidence
Azitromicin has been extensively studied in clinical trials, demonstrating its efficacy and safety in the management of various bacterial infections. Notably, research published in the Journal of Antimicrobial Chemotherapy highlighted the comparable effectiveness of azithromycin in treating community-acquired pneumonia when compared to other standard antibiotics, with the added benefit of a simplified dosing schedule.
