Description
Azomex (S-amlodipine besilate) Tablets 5 mg. №30
Composition
Each tablet contains: S-amlodipine besilate 5 mg.
Mechanism of Action
S-amlodipine besilate, the active ingredient in Azomex tablets, is a calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle cells, resulting in vasodilation and reduced peripheral vascular resistance.
Pharmacological Properties
Azomex tablets exert antihypertensive effects by relaxing blood vessels and improving blood flow, thereby lowering blood pressure and reducing the workload of the heart. The medication also helps in the management of coronary artery disease by increasing myocardial oxygen delivery in patients with vasospastic and obstructive angina.
Indications for Use
Azomex tablets are indicated for:
- Treatment of hypertension
- Management of coronary artery disease, including vasospastic and obstructive angina
Contraindications
Azomex tablets should not be used if:
- The patient is allergic to amlodipine or any component of the formulation
- The patient has severe hypotension
Side Effects
Common side effects of Azomex tablets may include peripheral edema, headache, dizziness, fatigue, and flushing. Patients should consult a healthcare provider if these side effects persist or worsen.
Usage Instructions
Recommended Dosage: Take 1 tablet of Azomex (S-amlodipine besilate 5 mg) orally once daily. The tablets can be taken with or without food. It is advisable to swallow the tablet whole with a glass of water.
Benefits Compared to Analogues
Azomex tablets containing S-amlodipine besilate offer advantages over racemic amlodipine formulations due to their enhanced efficacy in lowering blood pressure and managing coronary artery disease. The medication provides superior clinical outcomes and improved tolerability profiles compared to traditional amlodipine formulations.
Suitable Patient Groups
Azomex tablets are suitable for adult patients with hypertension and coronary artery disease. The dosage may need adjustment in elderly patients or those with hepatic impairment. Pediatric use should be determined by a healthcare professional based on individual patient needs.
Storage and Shelf Life
Azomex tablets should be stored at room temperature, away from moisture and heat. The shelf life of the product is as indicated on the packaging. Keep the tablets in the original packaging to protect them from light and moisture.
Packaging Description
Azomex tablets are supplied in a package containing 30 tablets. The packaging is designed to maintain the stability and integrity of the tablets throughout their shelf life. Each tablet is individually sealed to ensure product quality and safety.
Clinical Evidence and Proven Effectiveness
Azomex (S-amlodipine besilate) tablets have demonstrated significant efficacy in clinical trials for the management of hypertension and coronary artery disease.
A study published in the Journal of Clinical Pharmacology highlighted the superior efficacy of S-amlodipine besilate in reducing blood pressure compared to racemic amlodipine formulations.
