Description

Pharmachologic effect of Actovegin ampoules

Pharmacotherapeutic group: tissue regeneration stimulator

ATX code: B06AB

Actovegin ampoules Pharmacodynamics

Antihypoxant. Actovegin® is a hemoderivate, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5000 daltons pass). It has a positive effect on the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of the plasma membranes of cells during ischemia and a decrease in lactate formation), thus having an antihypoxic effect, which begins to manifest itself no later than 30 minutes after parenteral administration and reaches a maximum on average after 3 hours (2-6 hours).

Actovegin® increases the concentration of adenosine triphosphate, adenosine diphosphate, phosphocreatine, as well as amino acids – glutamate, aspartate and gamma-aminobutyric acid.

The effect of Actovegin® on oxygen uptake and utilization, as well as insulin-like activity with stimulation of glucose transport and oxidation, are significant in the treatment of diabetic polyneuropathy (DPN). In patients with diabetes mellitus and diabetic polyneuropathy, Actovegin® significantly reduces the symptoms of polyneuropathy (stabbing pain, burning sensation, paresthesia, numbness in the lower extremities).

Sensitivity disorders are objectively reduced, and the mental well-being of patients improves.

Indications

Metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury).
Peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers); diabetic polyneuropathy
Wound healing (ulcers of various etiologies, burns, trophic disorders (bedsores), impaired wound healing processes).
Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy

Use during pregnancy and lactation

The use of the drug in pregnant women did not cause negative effects on the mother or fetus. However, when used in pregnant women, the potential risk to the fetus must be considered.

Contraindications