Description

Composition

active ingredient: 1 ml of the drug contains: deproteinized hemoderivat from the blood of calves in the form of Actovegin concentrate, 40 mg of dry weight;

excipients: sodium chloride, water for injection.

Indications for Actovegin ampoules 80 mg.

Treatment of brain diseases of vascular origin, including post-stroke cognitive impairment and dementia.
Treatment of peripheral (arterial, venous) circulation disorders and their complications (arterial angiopathy, venous trophic ulcer).
Treatment of diabetic polyneuropathy (DPN).

Contraindications

Hypersensitivity to the active substance, any component of Actovegin ampoules 400 mg or to drugs of a similar composition. Decompensated heart failure, pulmonary edema, oliguria, anuria are common contraindications to infusion therapy, therefore, the administration of the drug in the form of infusions in these conditions is contraindicated, taking into account possible overhydration.

Dosage and administration of Actovegin ampoules 80 mg.

Intramuscularly, the solution is administered slowly, no more than 5 ml per day, since it is hypertonic. For specific indications, dosage selection is based on clinical trial data.

General dosage recommendations are also provided.

In the treatment of diseases of the brain of vascular origin. General dosage regimen: Initially 10 ml (400 mg) intravenously daily for 2 weeks, then 5-10 ml (200-400 mg) intravenously several times a week for at least 4 weeks.

Dosage for post-stroke cognitive impairment and dementia: Initially, 50 ml (2000 mg) per day as an intravenous infusion up to a maximum of 20 infusions, followed by a switch to Actovegin tablets.

In the treatment of peripheral (arterial, venous) circulation disorders and their complications (arterial angiopathy, venous trophic ulcer). General dosage regimen: Depending on the severity of the patient’s condition and the clinical picture, 10-20 ml (400-800 mg) are first injected intravenously or intra-arterially every day; for subsequent treatment, 5 ml (200 mg) is administered intravenously or slowly intramuscularly every day or several times a week.

Dosing regimen for violations of the peripheral arterial circulation of the IIb stage according to Fontaine: Initially, 30 ml (1200 mg) per day as an intravenous infusion for 2 weeks, followed by a switch to treatment with Actovegin tablets.

Dosing regimen for arterial angiopathy: Initially, 20-50 ml (800-2000 mg) IV or IA every day or several times a week; total duration up to 4 weeks.

Dosage regimen for venous trophic ulcer: Initially 10 ml (400 mg) IV or 5 ml (200 mg) IM daily or several times a week depending on the healing process. For a large ulcer, 25 ml (1000 mg) as an intravenous infusion daily for 4 weeks.

In the treatment of diabetic polyneuropathy (DPN). General dosage regimen: Depending on the severity of the clinical picture, first 10-20 ml (400-800 mg) intravenously or intra-arterially every day; for subsequent treatment 5 ml (200 mg) intravenously or slowly intramuscularly every day or several times a week.

Dosage for symptomatic diabetic distal polyneuropathy in patients with type 2 diabetes mellitus: Initially, 50 ml (2000 mg) per day as an intravenous infusion up to a maximum of 20 infusions for a maximum of 36 days, followed by switching to Actovegin tablets.