Description

Adenuric (febuxostat) Coated Tablets 80 mg. №28

Ingredients

Active ingredient: Febuxostat 80 mg.
Inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, triacetin.

Dosage

Recommended dosage: The usual dose is 80 mg once daily. Adjustments may be made based on individual response.

Indications

Adenuric (febuxostat) tablets are indicated for the management of hyperuricemia in patients with gout.

Contraindications

Do not use Adenuric tablets in patients with severe liver disease or a history of severe hypersensitivity reactions to febuxostat.

Directions

Take Adenuric tablets orally with or without food. Swallow the tablet whole with water. Do not crush or chew the tablet.

Scientific Evidence

Studies have shown that febuxostat effectively lowers serum uric acid levels in patients with hyperuricemia. In a randomized controlled trial by Becker et al., febuxostat demonstrated superior efficacy compared to allopurinol in achieving target uric acid levels.

Additional Information

It is important to monitor liver function tests during treatment with Adenuric tablets, especially in patients with pre-existing liver conditions. Adverse reactions may include nausea, rash, and elevated liver enzymes.

Pharmacological Effects: Febuxostat is a xanthine oxidase inhibitor that works by decreasing the production of uric acid in the body. By lowering uric acid levels, it helps prevent gout attacks and complications associated with hyperuricemia.

Clinical Trials: In a multicenter, double-blind study by Schumacher et al., febuxostat was found to be non-inferior to allopurinol in reducing serum urate levels in patients with gout. The study also reported a lower rate of gout flares in the febuxostat group.