Advantan (methylprednízolon) cream 0.1% 15 g. tube №1

Description

Pharmachologic effect

GCS for external use is a non-halogenated synthetic steroid. When applied externally, Advantan suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).

When using methylprednisolone aceponate externally, the systemic effect is minimally expressed both in humans and in animals. After repeated application of Advantan on large surfaces (40-60% of the skin surface), as well as when applied under an occlusive dressing, there are no adrenal dysfunctions: the level of cortisol in the blood plasma and its circadian rhythm remain within the normal range, there is no decrease in the level of cortisol in daily urine. happening.

In the course of clinical studies with the use of Advantan in the form of an ointment, cream, fatty ointment or emulsion for up to 12 weeks in adults and up to 4 weeks in children (including young children), there was no development of skin atrophy, telangiectasias, striae and acne-like rashes.

Methylprednisolone aceponate (especially its main metabolite, 6α-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to specific regions of DNA, thus causing a series of biological effects. In particular, the binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and thus the formation of inflammatory mediators such as prostaglandins and leukotrienes. GCS inhibition of the synthesis of vasodilating prostaglandins and potentiation of the vasoconstrictive action of adrenaline leads to a vasoconstrictor effect.

Indication for use

Inflammatory skin diseases sensitive to topical GCS therapy:

• atopic dermatitis, neurodermatitis, children’s eczema;
• true eczema; microbial eczema;
• occupational eczema;
• dyshidrotic eczema;
• simple contact dermatitis;
• allergic (contact) dermatitis.

Dosage and Administration

For adults and children from 4 months, the drug is applied 1 time / day with a thin layer on the affected skin. Continuous daily use of Advantan in the form of a cream is for adults no more than 12 weeks, for children – no more than 4 weeks. Advantan cream is a dosage form with a low fat content and a high water content, therefore it is recommended for the treatment of acute inflammatory processes and the weeping stage of eczema in very oily skin, as well as in the localization of the process both on smooth skin and on the scalp. If the skin is excessively dry with prolonged use of the cream, it is necessary to switch to the dosage form of Advantan.

Contraindications

• Skin tuberculosis and skin manifestations of syphilis in the area of application of the drug;
• viral skin lesions in the area of ​​application of the drug (for example, with chicken pox, shingles);
• rosacea, perioral dermatitis in the area of application of the drug;
• skin manifestations of reaction to vaccination;
• children up to 4 months;
• hypersensitivity to the components of the drug.

Special instructions

In the presence of bacterial dermatoses and / or dermatomycosis, in addition to therapy with Advantan, it is necessary to carry out specific antibacterial or antifungal treatment.

Avoid getting the drug in the eyes. As with the use of systemic corticosteroids, glaucoma may develop with topical corticosteroids (for example, after high doses or very prolonged use, use of occlusive dressings or application to the skin around the eyes).

Does not affect the ability to drive vehicles and work with mechanisms.