Afloderm (alclometasone) ointment 0.5 mg/g. 20 g. tube

Description

Composition

active substance: alclometasone dipropionate;

• 1 g of ointment contains 0.5 mg of alclometasone dipropionate;

excipients: white soft paraffin, white wax, hexylene glycol, propylene glycol monopalmitostearate.

The main physical and chemical properties:

homogeneous ointment from colorless to light yellow without foreign inclusions.

Pharmacotherapeutic group

Corticosteroids for use in dermatology.

ATX code D07A B10.

Pharmacodynamics

Alclometasone is a synthetic, non-fluorinated, moderately active corticosteroid for local use. It has an anti-inflammatory, antipruritic, immunosuppressive, vasoconstrictor and antiproliferative effect.

Anti-inflammatory activity is associated with a decrease in the production, release and activity of factors that mediate inflammation, such as quinine, histamine, lysosomal enzymes, prostaglandins, and leukotrienes, which contribute to the development of the inflammatory process.

Corticosteroids prevent the expansion of blood vessels and increase their porosity, accordingly, the migration of inflammatory cells to the cells of the damaged tissue decreases. This effect reduces serum extravasation, swelling and pain.

The immunosuppressive effect is manifested in the inhibition of early hypersensitivity reactions (III and IV types). The mechanism of activity is manifested in the reduction of the toxic effect of the antigen-antibody complex, which settles on the walls of blood vessels and leads to the occurrence of allergic vasculitis on the one hand, and the reduction of the activity of lymphokines, target cells and macrophages, which together lead to the development of the reaction of allergic contact dermatitis on the other side

Corticosteroids also prevent the access of sensitized T-lymphocytes and macrophages to target cells.

The antiproliferative effect of alclometasone is manifested in the reduction of the number of hyperplastic tissues, which are typical for psoriasis.

Pharmacokinetics

With local application of alclometasone on intact, healthy skin, 3% of the total amount of the drug is absorbed into the systemic circulation. Damage to the skin or the use of an occlusive bandage can increase the absorption of alclometasone.

Alclometasone dipropionate is metabolized primarily in the liver; metabolites are mainly excreted in the urine and a smaller part is excreted in the bile.

Indication

Treatment of dermatoses sensitive to treatment with local corticosteroids (including atopic and contact dermatitis, psoriasis).

For treatment:

• dermatoses on areas of the skin with increased sensitivity (for example, the face, areas of diaper rash);
• chronic dermatoses in patients with sensitive skin (children and elderly patients);
• large areas of skin, especially in children – due to minimal systemic absorption;
• dermatoses that require continued treatment after the use of stronger corticosteroids.

Contraindications of Afloderm

• Hypersensitivity to alclometasone or other components of the drug,
• acne,
• pink acne,
• lupus,
• skin manifestations of syphilis,
• skin reactions after vaccination,
• viral infections (for example, herpes simplex, shingles, chicken pox),
• perioral dermatitis,
• rosacea,
• molluscum contagiosum,
• fungal and bacterial skin lesions,
• varicose veins,
• open wounds

It should not be used under occlusive bandages.