Aflubin Penciclovir (Penciclovir) cream 1% 2g.

Description

Pharmacodynamics.

Penciclovir exhibits high selectivity in vivo and in vitro against human herpes viruses Herpes simplex (type 1 and 2), including against acyclovir-resistant strains with altered DNA polymerase, Varicella zoster virus, as well as Epstein-Barr virus and cytomegalovirus. In virus-infected cells, penciclovir is rapidly converted to triphosphate (with the participation of thymidine kinase, which is induced by the virus). Penciclovir triphosphate remains in virus-infected cells for more than 12 hours, where it inhibits the replication of viral DNA, that is, much longer than acyclovir. By blocking the reproduction of the virus, penciclovir significantly shortens the healing time, even after the development of papules and blisters, reduces pain and the duration of the crusting period, which is formed during the viral action. The half-life is 9, 10, and 20 hours in cells infected with Varicella zoster viruses, Herpes simplex type 1 and Herpes simplex type 2, respectively. In uninfected cells treated with penciclovir, the concentration of penciclovir triphosphate is practically undetectable. Thus, penciclovir does not affect cells that are not infected with the virus.

Indication

Herpes of the lips (Herpes labialis).

Contraindications of Aflubin Penciclovir

Hypersensitivity to penciclovir, famciclovir or other components of the drug (for example, propylene glycol).

Indications for use

The cream should be applied only to the herpes affected areas on the lips or on the skin around the mouth. It is not recommended to apply the cream on mucous membranes (for example, eyes, mouth, nose or genitals). Special care should be taken to avoid getting the cream in the eyes or on the areas around them.

If the symptoms of the disease have not disappeared after 4 days of Penciclovir cream therapy, you should consult a doctor.

To prevent the spread of the virus to other parts of the body and not to infect the surrounding people, the following rules should be followed:

• always wash your hands before and after touching the affected area;
• keep the cream tube in the original packaging, do not allow other people to use the cream;
• try not to puncture blisters formed as a result of prolonged viral action;
• try not to rub your eyes (the virus can affect the cornea of ​​the eye);
• avoid kissing, especially with children;
• avoid sharing things through which the virus can spread: towels, cups, tableware, cigarettes.

The cream contains cetostearyl alcohol, which can cause local skin reactions (for example, contact dermatitis). The cream also contains propylene glycol, which can cause skin irritation.

Penciclovir cream should be applied every 2 hours (except during sleep). The course of treatment is 4 days. Treatment should be started as early as possible at the first signs of infection.