Description

Agapurin SR (pentoxifyllin) Coated Tablets with Prolonged Release 400 mg. №20

Ingredients:

Each coated tablet contains 400 mg of pentoxifylline.

Dosage:

The usual dose is one tablet twice a day, preferably with meals.

Indications:

Agapurin SR is indicated for the treatment of peripheral vascular diseases. It helps improve blood flow and reduces the viscosity of blood, which can benefit individuals with circulation issues.

Contraindications:

Do not use Agapurin SR if you have a history of bleeding disorders or recent hemorrhage. It is also contraindicated in patients with acute myocardial infarction and those prone to allergic reactions to the drug.

Directions:

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence:

Pentoxifylline, the active ingredient in Agapurin SR, has been extensively studied for its effects on peripheral vascular diseases. Research published in the Journal of Vascular Surgery demonstrated that pentoxifylline can improve symptoms and increase walking distance in patients with intermittent claudication. Additionally, a meta-analysis published in the Cochrane Database of Systematic Reviews supported the use of pentoxifylline for improving blood flow and symptoms in individuals with peripheral artery disease.

Additional Information:

Agapurin SR with prolonged release offers a convenient dosing regimen for individuals requiring long-term management of peripheral vascular diseases. It is important to adhere to the prescribed dosage and consult a healthcare professional for personalized recommendations. If you experience any adverse effects or have concerns about the medication, seek medical advice promptly.

Pharmacological Effects: Pentoxifylline works by improving blood flow through its vasodilatory and anti-inflammatory properties. It helps reduce blood viscosity and enhance red blood cell flexibility, leading to improved circulation in the peripheral vessels.

Clinical Trials: Clinical trials have shown that Agapurin SR can effectively improve symptoms such as leg pain and cramping associated with peripheral vascular diseases. A study published in the European Journal of Vascular and Endovascular Surgery reported significant improvements in walking distance and quality of life in patients treated with pentoxifylline compared to a control group.