Description

Agapurin SR (Pentoxifyllin) Coated Tablets with Prolonged Release 400 mg. №20

Ingredients:

• Each coated tablet contains 400 mg of pentoxifylline.

Dosage:

• The usual dose is one tablet twice a day, preferably with meals.

Indications:

• Agapurin SR is indicated for the treatment of peripheral vascular diseases.
• It helps improve blood flow and reduces the viscosity of blood, which can benefit individuals with circulation issues.

Contraindications:

• Do not use Agapurin SR if you have a history of bleeding disorders or recent hemorrhage.
• It is also contraindicated in patients with acute myocardial infarction and those prone to allergic reactions to the drug.

Directions:

• Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
• Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence:

• Pentoxifylline, the active ingredient in Agapurin SR, has been extensively studied for its effects on peripheral vascular diseases.
• Research published in the Journal of Vascular Surgery demonstrated that pentoxifylline can improve symptoms and increase walking distance in patients with intermittent claudication.
• A meta-analysis published in the Cochrane Database of Systematic Reviews supported the use of pentoxifylline for improving blood flow and symptoms in individuals with peripheral artery disease.

Additional Information:

• Agapurin SR with prolonged release offers a convenient dosing regimen for individuals requiring long-term management of peripheral vascular diseases.
• It is important to adhere to the prescribed dosage and consult a healthcare professional for personalized recommendations.
• If you experience any adverse effects or have concerns about the medication, seek medical advice promptly.

Pharmacological Effects: Pentoxifylline works by improving blood flow through its vasodilatory and anti-inflammatory properties. It helps reduce blood viscosity and enhance red blood cell flexibility, leading to improved circulation in the peripheral vessels.

Clinical Trials: Clinical trials have shown that Agapurin SR can effectively improve symptoms such as leg pain and cramping associated with peripheral vascular diseases. A study published in the European Journal of Vascular and Endovascular Surgery reported significant improvements in walking distance and quality of life in patients treated with pentoxifylline compared to a control group.