$9.00
Manufacturer: India
Aleric is intended for the treatment of patients with allergic rhinitis (including year-round and seasonal allergic rhinitis), as well as allergic conjunctivitis.
Aleric is also prescribed for patients with chronic idiopathic urticaria and allergic dermatitis.
Description
Composition
1 tablet of Aleric contains:
Loratadine – 10 mg;
Additional ingredients including lactose anhydrous.
Pharmachodinamics
Aleric is an antihistamine. Loratadine is a medicinal substance that is part of the drug. Loratadine is a derivative of piperidine, a second-generation antiallergic drug with a long-lasting antihistamine effect. The drug selectively blocks peripheral H1-histamine receptors. Loratadine practically does not bind to histamine receptors of the central nervous system and has no affinity for other biogenic amine receptors. Due to the size of the molecule and the high degree of binding to plasma proteins, it practically does not penetrate the blood-brain barrier.
The drug is characterized by anti-exudative, antipruritic and anti-allergic activity, loratadine also reduces capillary permeability and has a decongestant effect.
The therapeutic effect of the drug Aleric develops after 1-3 hours and reaches a maximum after 8-12 hours after administration. The effect of the drug lasts from 24 to 48 hours.
After oral administration, loratadine is well absorbed from the gastrointestinal tract. The maximum plasma concentration of the active ingredient is observed 1-2 hours after ingestion. About 99% of loratadine binds to plasma proteins. Steady-state plasma concentrations of loratadine are reached on day 5 of taking Aleric.
Metabolized loratadine in the liver with the participation of the cytochrome P450 system (in particular CYP 34A and CYP 2D6). The drug is metabolized with the formation of a pharmacologically active metabolism and a number of inactive substances.
The half-life reaches 7.5-11 hours, the active component and metabolites are excreted mainly in the urine, a small part is excreted in the feces.
There is no accumulation of loratadine in the body, including with prolonged use. In children over the age of 2 years, the pharmacokinetics of the drug does not differ from that in adults.
Aleric passes into breast milk.
Indications for use
Aleric is intended for the treatment of patients with allergic rhinitis (including year-round and seasonal allergic rhinitis), as well as allergic conjunctivitis.
Aleric is also prescribed for patients with chronic idiopathic urticaria and allergic dermatitis.
Mode of application
Aleric is intended for oral use. The drug is taken regardless of the meal. If necessary, the tablets can be divided. The daily dose is taken at a time, it is recommended to take Aleric at the same time of day. The duration of therapy and the dose of loratadine is determined by the attending physician, depending on the severity of the symptoms and the patient’s personal characteristics.
Adults and children weighing more than 30 kg are recommended to prescribe loratadine in a daily dose of 10 mg (1 tablet of Aleric).
For children under 12 years of age weighing less than 30 kg, loratadine is prescribed in a daily dose of 5 mg (1/2 tablet of Aleric).
The recommended duration of therapy is 10 days. If necessary, therapy with the drug is extended, taking into account the tolerability and efficacy of loratadine.
Aleric should be discontinued 7 days prior to skin allergy testing.
Side effects
Aleric is usually well tolerated by patients. In isolated cases, mainly in patients with hypersensitivity, fatigue, headache, dryness of the oral mucosa, nausea and drowsiness may develop. In addition, the development of fainting, heart rhythm disturbances, baldness, liver dysfunction, skin rash and anaphylaxis is possible.
Contraindications
Aleric is contraindicated in case of individual hypersensitivity to loratadine and other substances that make up the drug.
The drug should not be prescribed to patients with galactosemia, glucose-galactose malabsorption syndrome and lactase deficiency.
Aleric should not be used during pregnancy and lactation.
Loratadine is not prescribed to children under 2 years of age.
Caution should be observed when prescribing Aleric to patients with severe renal impairment (including acute renal failure, patients with creatinine clearance less than 30 ml / min need to adjust the dose of loratadine), as well as to elderly patients.
Patients whose work requires increased concentration of attention should take loratadine with caution.
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