Alfa-lipon (alpha-lipoic (thioctic) acid) coated tablets 600 mg. №30

Alfa-lipon (alpha-lipoic (thioctic) acid) coated tablets 600 mg. №30

$43.00

Manufacturer: Ukraine

Drugs that affect the digestive system and metabolic processes. ATX code A16A X01.

Indicated for paresthesia in diabetic polyneuropathy.

The daily dose is 600 mg of thioctic acid (2 tablets of 300 mg or 1 tablet of 600 mg), which should be taken as a single dose 30 minutes before the first meal. Simultaneous ingestion of food complicates absorption, so for patients who are characterized by prolonged gastric emptying, it is especially important to take medications before eating. Tablets should not be chewed and washed down with a sufficient amount of liquid, for example, 1 glass of water.
With intense paresthesia, treatment can begin with parenteral administration of thioctic acid, using appropriate dosage forms.

Category:

Description

Composition

active ingredient : 1 tablet contains alpha-lipoic (thioctic) acid 300 mg or 600 mg;

excipients: lactose, monohydrate; cellulose microcrystalline; croscarmellose sodium; corn starch; sodium lauryl sulfate; silicon dioxide colloidal anhydrous; magnesium stearate;

Shell: Opadry II Yellow Film Coating Blend (lactose, monohydrate; hypromellose (hydroxypropyl methylcellulose); polyethylene glycol (macrogol); indigotine (E 132); sunset yellow FCF (E 110); quinoline yellow (E 104); titanium dioxide (E 171 ); triacetin).

Pharmacotherapeutic group

Drugs that affect the digestive system and metabolic processes. ATX code A16A X01.

Pharmacodynamics

Alpha-lipoic acid is an endogenous vitamin-like substance that acts as a coenzyme and takes part in the oxidative decarboxylation of α-keto acids. Due to hyperglycemia that occurs in diabetes mellitus, glucose is attached to the matrix proteins of blood vessels and the so-called “end products of accelerated glycolysis” are formed. This process leads to a decrease in endoneural blood flow and endoneural hypoxia/ischemia, which, in turn, leads to an increased formation of oxygen-containing free radicals that damage peripheral nerves. Decreased levels of antioxidants such as glutathione in peripheral nerves have also been noted.

Pharmacokinetics

After oral administration, thioctic acid is rapidly absorbed. As a result of significant first pass metabolism, the absolute bioavailability of thioctic acid is approximately 20%. Due to the rapid distribution in tissues, the plasma half-life of thioctic acid is approximately 25 minutes. The relative bioavailability of thioctic acid in oral administration of solid dosage forms is over 60% in proportion to the drinking solution. The maximum plasma concentration of about 4 μg / ml was measured approximately 30 minutes after oral administration of 600 mg of thioctic acid. In the urine, only a small amount of the substance in an unchanged state is determined. Biotransformation is carried out by oxidative reduction of the side chain (β-oxidation) and/or S-methylation of the corresponding thiols. Thioctic acid in vitro reacts with complexes of metal ions, for example, with cisplatin, and forms sparingly soluble complexes with sugar molecules.

Indications

Paresthesia in diabetic polyneuropathy.

Contraindications

Hypersensitivity to thioctic acid or to any of the components of the drug.

Dosage and administration

The daily dose is 600 mg of thioctic acid (2 tablets of 300 mg or 1 tablet of 600 mg), which should be taken as a single dose 30 minutes before the first meal. Simultaneous ingestion of food complicates absorption, so for patients who are characterized by prolonged gastric emptying, it is especially important to take medications before eating. Tablets should not be chewed and washed down with a sufficient amount of liquid, for example, 1 glass of water.

With intense paresthesia, treatment can begin with parenteral administration of Alpha-lipoic acid, using appropriate dosage forms.

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