Alfort Dexa (dexketoprofen trometamol) solution for injections 50 mg/2 ml. ampoules 2 ml. №5

the active substance: dexketoprofen trometamol;

1 ml solution for injection contains dexketoprofen trometamol 36.9 mg, equivalent to dexketoprofen 25 mg (1 2 ml ampoule contains dexketoprofen trometamol 73.8 mg, equivalent to dexketoprofen 50 mg);

other ingredients: ethanol (96%), sodium chloride, sodium hydroxide, water for injection.

Nonsteroidal anti-inflammatory and antirheumatic drugs. Derivatives of propionic acid. Dexketoprofen. ATX Code  M01A E17.

Dexketoprofen trometamol is a salt of propionic acid that has analgesic, anti-inflammatory and antipyretic effects and belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). The mechanism of its action is based on a decrease in the synthesis of prostaglandins due to the inhibition of cyclooxygenase. In particular, the conversion of arachidonic acid into cyclic endoperoxides PGG2 and PGH2 is inhibited, from which prostaglandins PGE1, PGE2, PGF2a, PGD2, as well as prostacyclin PGI2 and thromboxanes TxA2 and TxB2 are formed. In addition, inhibition of prostaglandin synthesis may affect other inflammatory mediators such as kinins, which may also indirectly affect the main effect of the drug. An inhibitory effect of dexketoprofen trometamol on the activity of cyclooxygenase-1 and cyclooxygenase-2 was found. Clinical studies in various types of pain have shown that dexketoprofen trometamol has a pronounced analgesic effect. The analgesic effect of dexketoprofen trometamol when administered intramuscularly and intravenously to patients with pain of moderate to severe intensity was studied in various types of pain during surgical interventions (orthopedic and gynecological operations, abdominal operations), as well as pain in the musculoskeletal system. back pain and renal colic. During the studies, the analgesic effect of the drug appeared quickly and reached a maximum within the first 45 minutes. The duration of analgesic action after the use of dexketoprofen trometamol 50 mg is usually 8 hours. The studies carried out have shown that the use of the drug Alfort Dexa can significantly reduce the dose of opiates when they are used simultaneously to relieve postoperative pain. When dexketoprofen trometamol was also administered to patients who were prescribed morphine for postoperative pain relief using a patient-controlled analgesic device, they required significantly less morphine (30-45%) than patients who received placebo.

Symptomatic treatment of acute pain of moderate to severe intensity when oral administration of the drug is inappropriate, for example, with postoperative pain, renal colic and back pain.

• Hypersensitivity to dexketoprofen or to excipients of the drug;
• attacks of bronchial asthma, bronchospasm, acute rhinitis or the development of nasal polyps, urticaria or angioedema due to the use of drugs of similar action, such as acetylsalicylic acid or other NSAIDs;
• active peptic ulcer or bleeding, suspected bleeding or recurrent peptic ulcer or bleeding history (at least two confirmed ulcers or bleeding) or chronic dyspepsia;
• gastrointestinal bleeding, other bleeding in the active phase, or increased bleeding;
• history of gastrointestinal bleeding or perforation associated with pre-treatment with NSAIDs;
• Crohn’s disease or ulcerative colitis;
• bronchial asthma in history;
• severe heart failure;
• impaired renal function of moderate or severe degree (creatinine clearance < 50 ml / min);
• severe liver dysfunction (10-15 points on the Child-Pugh scale);
• hemorrhagic diathesis and other blood clotting disorders;
• III trimester of pregnancy and lactation period;
• use for the purpose of neuraxial (intrathecal or epidural) administration (due to the ethanol content).