Almer (donepezil hydrochloride) coated tablets 10 mg. №30

Almer is a drug used in the treatment of dementia due to the presence of nootropic, cerebrovasodilating, antihypoxic and psychostimulant pharmacological effects.

Pharmacodynamics

Almer is a selective and reversible blocker of acetylcholinesterase, the main type of cholinesterase in the brain. Having a blocking effect on cholinesterase in the brain, donepezil (the active ingredient of the drug) prevents the breakdown of acetylcholine, through which nerve impulses are transmitted to the central nervous system. The blocking of acetylcholinesterase under the action of donepezil occurs 1000 times more intensively than the blocking of butyrylcholinesterase, which is located in the body (excluding the central nervous system).

The degree of inhibitory effect on acetylcholinesterase is assessed in erythrocyte membranes. With a single application of Almera at a dose of 5 mg, it is 63.6%, 10 mg – 77.3%.

The use of Almer (donepezil hydrochloride) contributes to:

• reduce the progression of Alzheimer’s disease,
• reducing the intensity of cognitive impairment,
• increasing the daily activity of patients, which leads to an increase in their independence and a decrease in the necessary care,
• normalization of the patient’s behavior,
• a decrease in indifference and indifference to the events taking place around the patient and to the world around him as a whole,
• the disappearance of visions
• elimination of involuntary repetitive movements.

Indications for use

Almer (donepezil hydrochloride) is prescribed for adult patients suffering from Alzheimer’s disease in order to eliminate the symptoms of dementia, which manifests itself in mild to moderate form.

Contraindications

Almer (donepezil hydrochloride) is categorically contraindicated to patients with a history of reports of:

• hypersensitivity to the main and additional components of the composition,
• pregnancy and lactation period,
• children’s age (up to 18 years).