Description

Alzepil (donepezil) Coated Tablets 5 mg. №28

Ingredients

Each tablet contains 5 mg of donepezil hydrochloride.

Dosage

The recommended dosage is one 5 mg tablet daily, preferably taken at bedtime.

Indications

Alzepil (donepezil) is indicated for the treatment of mild to moderate Alzheimer’s disease.

Contraindications

Do not use Alzepil if you are allergic to donepezil or any other ingredients in the tablet.

Directions

Swallow the tablet whole with water. Do not crush or chew it.

Scientific Evidence

Studies have shown that donepezil, the active ingredient in Alzepil, is effective in improving cognitive function and slowing the progression of Alzheimer’s disease. Research published in the New England Journal of Medicine demonstrated the benefits of donepezil in enhancing memory and daily functioning in patients with Alzheimer’s.

Additional Information

It is important to note that Alzepil may cause side effects such as nausea, diarrhea, and insomnia. Patients should consult their healthcare provider if these side effects persist or worsen. Regular monitoring and dose adjustments may be necessary for optimal treatment outcomes.

Pharmacological Effects

Donepezil works by inhibiting acetylcholinesterase, an enzyme that breaks down acetylcholine in the brain. By inhibiting this enzyme, donepezil increases the levels of acetylcholine, a neurotransmitter involved in memory and learning processes. This mechanism of action helps improve cognitive function in patients with Alzheimer’s disease.

Clinical Trials and Comparative Effectiveness

In comparative studies, donepezil has shown similar efficacy to other cholinesterase inhibitors in the treatment of Alzheimer’s disease. A meta-analysis published in the Journal of Alzheimer’s Disease concluded that donepezil is well-tolerated and effective in improving cognitive function across different stages of Alzheimer’s.