Description

Amaril (glimepiride) tablets 2 mg. №30

Ingredients

Active ingredient: Glimepiride 2 mg.
Other ingredients: Lactose monohydrate, maize starch, povidone, and magnesium stearate.

Dosage

Dosage: The usual starting dose is 1-2 mg once daily with breakfast or the first main meal. Dosage adjustments should be made based on blood glucose levels.

Indications

Indications: Amaril tablets are indicated for the treatment of type 2 diabetes mellitus when diet, exercise, and weight reduction alone are not sufficient.

Contraindications

Contraindications: Do not use Amaril tablets in patients with a history of hypersensitivity to glimepiride or other sulfonylureas.

Directions

Directions: Swallow the tablet whole with a glass of water. It is recommended to take the medication at the same time each day.

Scientific Evidence

Scientific Evidence: Studies have shown that glimepiride effectively lowers blood glucose levels by stimulating insulin release from pancreatic beta cells. Research by Schernthaner G. et al. demonstrated the long-term efficacy and safety of glimepiride in the management of type 2 diabetes.

Additional Information

Storage: Store at room temperature away from moisture and heat.
Side Effects: Common side effects may include hypoglycemia, dizziness, and headache.

Pharmacological Effects: Glimepiride belongs to the sulfonylurea class of drugs, which work by increasing insulin release from the pancreas, thereby reducing blood sugar levels. It also improves insulin sensitivity in peripheral tissues, enhancing glucose uptake.

Clinical Trials: In a comparative study by Marre M. et al., glimepiride was found to be as effective as gliclazide in controlling blood glucose levels in patients with type 2 diabetes. The study highlighted the comparable efficacy and safety profiles of glimepiride.