Description

Amaril (glimepiride) tablets 4 mg. №30

Ingredients

Active ingredient: Glimepiride 4 mg per tablet.

Dosage

Dosage: The usual starting dose is 1 to 2 mg once daily. Dosage adjustments should be made based on blood glucose levels.

Indications

Indications: Amaril tablets are indicated for the treatment of type 2 diabetes mellitus when diet, exercise, and weight reduction alone are not sufficient.

Contraindications

Contraindications: Do not use Amaril in patients with a history of hypersensitivity to glimepiride or other sulfonylureas.

Directions

Directions: Take Amaril tablets orally with breakfast or the first main meal of the day. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Efficacy: Studies have shown that glimepiride, the active ingredient in Amaril, effectively lowers blood glucose levels by stimulating insulin release from pancreatic beta cells. Clinical trials have demonstrated its efficacy in improving glycemic control in patients with type 2 diabetes.

Pharmacological Action: Glimepiride belongs to the sulfonylurea class of drugs and works by increasing insulin secretion from the pancreas, thereby reducing blood sugar levels. It also improves insulin sensitivity in peripheral tissues.

Comparative Effectiveness: In comparative studies, glimepiride has shown similar efficacy in lowering blood glucose levels compared to other sulfonylureas. It has also been found to have a lower risk of hypoglycemia compared to some older sulfonylureas.

Additional Information

• Warnings: Amaril may cause hypoglycemia. Patients should be educated on the signs and symptoms of low blood sugar and how to manage it.
• Side Effects: Common side effects of glimepiride include dizziness, headache, and nausea. Consult your doctor if any side effects persist or worsen.