Ambrobene (ambroxol hydrochloride) solution 7.5 mg/ml. 100 ml.

Ambroxol hydrochloride – 7.5 mg / ml;

other ingredients: potassium sorbate, hydrochloric acid 25%, purified water.

Ambroxol hydrochloride solution increases the secretion of the glands of the respiratory tract. Ambroxol enhances the release of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity. This leads to an increase in mucus secretion and excretion and an improvement in mucociliary clearance.

Activation of fluid secretion and increased mucociliary clearance facilitate mucus clearance and reduce coughing.

A local anesthetic effect of ambroxol hydrochloride has been reported, which may be due to the ability to block sodium channels. In vitro studies have shown that ambroxol hydrochloride blocks neuronal sodium channels; binding was reversible and concentration dependent.

Ambroxol hydrochloride has shown anti-inflammatory activity in vitro. In vitro studies have shown that ambroxol hydrochloride significantly reduces cytokine release from the blood and tissue binding of mononuclear and polymorphonuclear cells.

A significant reduction in the severity of pain and redness in the throat in patients with pharyngitis was reported with the use of the drug.

After the use of ambroxol hydrochloride, the concentration of antibiotics (amoxicillin, cefuroxime, erythromycin) in bronchopulmonary secretion and sputum increases.

Secretolytic therapy in acute and chronic bronchopulmonary diseases associated with impaired bronchial secretion and weakening of mucus movement.

Hypersensitivity to ambroxol and / or to other components of the drug. For tablets and syrup also: rare hereditary conditions due to which incompatibility with excipients of the drug is possible.

Ambroxol hydrochloride solution is used after meals. The drug is dosed using a measuring cup. Take drops after meals, dissolved in a liquid (for example, water, tea or juice).

The mucolytic effect of ambroxol is enhanced by the use of large amounts of liquid.

Children over the age of 12 years and adults: in the first 2-3 days – 4 ml 3 times a day, then – 4 ml 2 times or 2 ml 3 times a day.

Children aged 2-5 years: 1 ml 3 times a day.

Children aged 6-12 years: 2 ml 2-3 times a day.

The duration of treatment depends on the characteristics of the course of the disease. Ambrobene solution should not be used for longer than 4-5 days without consulting a doctor.

In case of impaired renal function and severe liver disease, the drug can be taken only under medical supervision. In this case, it is recommended to reduce the dose and increase the time between doses of the drug.

In acute diseases, you should consult your doctor if the symptoms do not disappear and / or intensify, despite taking the drug Ambrobene.