Ambrobene (ambroxol hydrochloride) syrup 15 mg/5 ml. 100 ml.

active ingredient: ambroxol hydrochloride;

5 ml of syrup contain ambroxol hydrochloride 15 mg;

excipients : sorbitol solution, does not crystallize, propylene glycol, raspberry flavor, saccharin, purified water.

Syrup.

Basic physical and chemical properties: transparent, colorless or yellowish solution with raspberry flavor.

Drugs used for coughs and colds. mucolytic agents. ATX code R05C B06.

Ambroxol hydrochloride increases the secretion of the glands of the respiratory tract. Ambroxol enhances the release of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity. This results in increased secretion and mucus secretion and improved mucociliary clearance.

Activation of fluid secretion and increased mucociliary clearance facilitate mucus clearance and reduce coughing.

A local anesthetic effect of ambroxol hydrochloride has been reported, which may be due to the ability to block sodium channels. In vitro studies have shown that ambroxol hydrochloride blocks neuronal sodium channels; binding was reversible and concentration dependent.

Ambroxol hydrochloride has been shown to be anti-inflammatory in vitro. In vitro studies have found that ambroxol hydrochloride significantly reduces cytokine release from the blood and tissue binding of mononuclear and polymorphonuclear cells.

A significant reduction in pain and redness in the throat in patients with pharyngitis has been reported with the use of the drug.

After the use of ambroxol hydrochloride, the concentrations of antibiotics (amoxicillin, cefuroxime, erythromycin) in bronchopulmonary secretion and sputum increase.

Secretolytic therapy for acute and chronic broncho-pulmonary diseases associated with impaired bronchial secretion and weakening of mucus movement.

Hypersensitivity to ambroxol and / or other components of the drug.

Rare hereditary conditions through which incompatibility with the excipient of the drug is possible.

Ambrobene (ambroxol hydrochloride) syrup is taken orally after meals. After taking it, it is recommended to drink 1 glass of water. The mucolytic effect of ambroxol is enhanced by the use of large amounts of liquid.

Adults and children over 12 years old: in the first 2-3 days, 10 ml 3 times a day, then – 10 ml 2 times a day. If necessary, the therapeutic effect for adults and children over 12 years of age can be enhanced by increasing the dose to 20 ml 2 times a day.

For adults and children over 12 years of age, it is advisable to use a dosage form containing a high concentration of ambroxol hydrochloride (for example, Ambrobene solution 37.5 mg / 5 ml).

children:

• from 2 to 6 years – 2.5 ml 3 times a day;
• from 6 to 12 years – 5 ml 2-3 times a day.

The duration of treatment depends on the characteristics of the course of the disease.

Ambrobene syrup should not be used for longer than 4-5 days without consulting a doctor.