$8.00
Manufacturer: Serbia
The active substance of the syrup, ambroxol hydrochloride, increases the secretion of the glands of the respiratory tract. Ambroxol enhances the release of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity. This results in increased secretion and mucus secretion and improved mucociliary clearance. Improvement in mucociliary has been proven during clinical and pharmacological studies.
Activation of fluid secretion and increased mucociliary clearance facilitate mucus clearance and relieve coughing.
The local anesthetic effect of ambroxol hydrochloride, which may be due to sodium channel blocking properties, was observed in a rabbit eye model. In vitro studies have shown that ambroxol hydrochloride blocks neuronal sodium channels; binding was reversible and concentration dependent.
Description
Ingredients
active ingredient: ambroxol hydrochloride;
5 ml of syrup contain ambroxol hydrochloride 15 mg;
excipients: benzoic acid (E 210), glycerin (85%), sorbitol solution that does not crystallize, hydroxyethyl cellulose, raspberry flavor, purified water.
Dosage form
Syrup.
Basic physical and chemical properties: homogeneous transparent solution from colorless to yellowish.
Pharmacotherapeutic group
mucolytic agents. ATX code R05C B06.
Pharmacodynamics
The active substance of the syrup, ambroxol hydrochloride, increases the secretion of the glands of the respiratory tract. Ambroxol enhances the release of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity. This results in increased secretion and mucus secretion and improved mucociliary clearance. Improvement in mucociliary has been proven during clinical and pharmacological studies.
Activation of fluid secretion and increased mucociliary clearance facilitate mucus clearance and relieve coughing.
The local anesthetic effect of ambroxol hydrochloride, which may be due to sodium channel blocking properties, was observed in a rabbit eye model. In vitro studies have shown that ambroxol hydrochloride blocks neuronal sodium channels; binding was reversible and concentration dependent.
Ambroxol hydrochloride has been shown to be anti-inflammatory in vitro. Thus, ambroxol hydrochloride significantly reduces the release of cytokines from mononuclear and polymorphonuclear blood cells and tissues.
As a result of clinical trials involving patients with pharyngitis, a significant reduction in pain and redness in the throat was demonstrated when using the drug.
Due to the pharmacological properties of ambroxol, pain was quickly relieved in the treatment of diseases of the upper respiratory tract, which was observed in studies of the clinical efficacy of inhaled forms of ambroxol.
After the use of ambroxol hydrochloride, the concentrations of antibiotics (amoxicillin, cefuroxime, erythromycin) in bronchopulmonary secretion and sputum increase.
Indications
Secretolytic therapy for acute and chronic bronchopulmonary diseases associated with a violation of bronchial secretion and a weakening of the passage of mucus.
Contraindications
Ambrochem, syrup, 15 mg / 5 ml, should not be used in patients with hypersensitivity to ambroxol hydrochloride or other components of the drug.
Use the drug for children under 2 years of age as prescribed by a doctor.
Directions
Unless otherwise stated, the recommended dose of Ambrochem (ambroxol) syrup, is as follows:
- children under 2 years of age: 2.5 ml (1/2 scoop) 2 times a day (equivalent to 15 mg ambroxol hydrochloride per day);
- children 2-5 years: 2.5 ml (1/2 measuring spoon) 3 times a day (equivalent to 22.5 mg ambroxol hydrochloride per day);
- children 6-12 years old: 5 ml (1 scoop) 2-3 times a day (equivalent to 30-45 mg ambroxol hydrochloride per day);
- adults and children over 12 years of age: the dose is 10 ml (2 scoops) 3 times a day (equivalent to 90 mg ambroxol hydrochloride per day) for the first 2-3 days and then 10 ml (2 scoops) 2 times a day ( equivalent to 60 mg ambroxol hydrochloride per day).
If necessary, the therapeutic effect for adults and children over 12 years of age can be enhanced by increasing the dose to 20 ml 2 times a day (equivalent to 120 mg of ambroxol hydrochloride per day).
The syrup can be used regardless of the meal with the help of a measuring spoon, which is put into the package.
In general, there are no restrictions on the duration of use, but long-term therapy should be monitored.
Ambrochem (ambroxol) syrup should not be used for longer than 4-5 days without consulting a doctor.
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