Description

Amicacina (Amikacin) Sulfate Solution for Injections 250 mg/ml. 2 ml. Ampoules №1

Ingredients:

Composition: Amikacin sulfate, sodium citrate, sulfuric acid, and water for injection.

Mechanism of Action:

Pharmacological Properties: Amikacin, a broad-spectrum aminoglycoside antibiotic, exerts its bactericidal effect by inhibiting bacterial protein synthesis, ultimately leading to cell death. It demonstrates particular efficacy against aerobic, gram-negative bacteria.

Indications for Use:

Indications: Amicacina (Amikacin) Sulfate Solution for Injections is indicated for the treatment of severe infections caused by susceptible strains of bacteria.

Contraindications:

Contraindications: This product should not be used in patients with a known hypersensitivity to amikacin or any other aminoglycoside. Caution is advised in individuals with pre-existing renal impairment.

Side Effects:

Side Effects: Common side effects may include nephrotoxicity, ototoxicity, and neuromuscular blockade. Monitoring for these adverse reactions is essential during treatment.

Usage Instructions:

Dosage and Administration: The typical adult dosage is 15 mg/kg/day, divided into 2 or 3 equal doses. Dosage adjustments may be necessary based on renal function. Administration should be via intramuscular or intravenous injection using proper aseptic techniques.

Benefits Compared to Analogues:

Advantages: Amikacin has demonstrated efficacy in treating severe bacterial infections, including those resistant to other antibiotics. Its broad-spectrum activity and potency make it a valuable option in challenging cases.

Suitable Patient Groups:

Patient Groups: This product is suitable for use in both adult and pediatric populations. Dosage adjustments may be required in elderly patients or those with renal impairment.

Storage and Shelf Life:

Storage: Store in a cool, dry place away from light. Do not freeze. Check the expiration date on the packaging and do not use beyond that date.

Packaging Description:

Packaging: Each package contains ampoules of Amicacina (Amikacin) Sulfate Solution for Injections, with a concentration of 250 mg/ml in 2 ml ampoules.

Scientific Evidence:

Amikacin, the active ingredient in Amicacina, has been extensively studied for its efficacy in treating severe bacterial infections. Research published in the Journal of Antimicrobial Chemotherapy has highlighted the effectiveness of amikacin against multidrug-resistant Gram-negative bacteria, showcasing its importance in combating challenging infections.

Additional Information:

• Pharmacological Effects: Amikacin’s mechanism of action involves inhibiting bacterial protein synthesis, leading to cell death. Its activity is particularly notable against aerobic, gram-negative bacteria.
• Clinical Trials: Clinical trials have demonstrated the tolerability and effectiveness of amikacin in treating various infections, including those caused by challenging pathogens such as Pseudomonas aeruginosa and Acinetobacter species.