Amicacina (amikacin) sulfatee solution for injections 250 mg/ml. 4 ml. ampoules №1

Amikacin sulfate solution 250 mg/ml. 4 ml. ampoules №1

$9.00

Manufacturer: Ukraine

Antimicrobial agents for systemic use. Aminoglycosides. Amikacin. ATX code J01G B06.

Amikacin sulfate solution is prescribed intramuscularly or intravenously (stream or drip). The dose and method of administration of the drug is determined individually for each patient, depending on the severity of the disease, the sensitivity of the pathogen, kidney function and body weight of the patient. Adults and children over 12 years old 10-15 mg/kg per day. The daily dose is divided into 2 injections. The maximum daily dose for adults is 1.5 g. The duration of treatment with intravenous administration is 3-7 days, with administration – 7-10 days.

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Description

Ingredients

active ingredient: amikacin;

1 ml of solution contains amikacin sulfate in terms of amikacin 50 mg or 250 mg;

excipients: sodium metabisulphite (E 223), sodium citrate, water for injection.

Pharmacotherapeutic group

Antimicrobial agents for systemic use. Aminoglycosides. Amikacin. ATX code J01G B06.

Pharmacodynamics

Amikacin is a semi-synthetic broad-spectrum aminoglycoside antibiotic. Amikacin actively penetrates the bacterial cell membrane. By binding to the 30S subunit of ribosomes, it interferes with the formation of a complex of transport and messenger RNA, blocks protein synthesis, and also disrupts the synthesis of the bacterial cytoplasmic membrane.

Active against aerobic Gram-negative microorganisms: Pseudomonas aeruginosa, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp., Enterobacter spp., Providencia spp., Proteus spp. (indole-positive and indole-negative strains), Serratia spp., Acinetobacter species, Citrobacter freundii.

Active against some gram-positive microorganisms: Staphylococcus spp ., incl. staphylococci resistant to penicillin, methicillin, some cephalosporins and some strains of Streptococcus pyogenes, Streptococcus pneumoniae, Enterococcus . Amikacin, under certain conditions, can be used as basic therapy for established diagnosis or suspected disease caused by susceptible strains of staphylococci, in patients allergic to other antibiotics and in mixed staphylococcal-gram-negative infections. Amikacin is inactive against anaerobic pathogens.

Indications

Infections caused by amikacin-sensitive strains of microorganisms resistant to other aminoglycosides.

Contraindications

  • kidney failure;
  • acoustic neuritis;
  • hypersensitivity to amikacin or to any other antibiotic of the aminoglycoside group and their derivatives;
  • hypersensitivity to any of the excipients that make up the drug;
  • myasthenia gravis;
  • dysfunction of the vestibular apparatus;
  • azotemia (residual nitrogen above 150 mg%);
  • prior treatment with ototoxic or nephrotoxic drugs.

Directions

Amikacin sulfate solution is prescribed intramuscularly or intravenously (stream or drip). The dose and method of administration of the drug is determined individually for each patient, depending on the severity of the disease, the sensitivity of the pathogen, kidney function and body weight of the patient. Adults and children over 12 years old 10-15 mg/kg per day. The daily dose is divided into 2 injections. The maximum daily dose for adults is 1.5 g. The duration of treatment with intravenous administration is 3-7 days, with administration – 7-10 days.

For uncomplicated infections of the genitourinary system (except for infections caused by Pseudomonas aeruginosa), the drug is administered intramuscularly at 250 mg 2 times a day for 5-7 days.

For infections caused by Pseudomonas aeruginosa and for life-threatening infections, the drug is prescribed at a dose of 15 mg / kg per day, divided into 3 injections.

For neonates and premature infants, the initial loading dose is 10 mg/kg per day followed by a daily dose of 15 mg/kg divided into 2 doses for 7-10 days.

In patients with impaired renal function, the daily dose should be reduced or the interval between doses should be increased to avoid cumulation of the antibiotic. It is necessary to adjust the dosing regimen depending on the creatinine clearance.

 

Creatinine clearance, mg/ml Number of injections Dose, mg/kg
80 1 time per 24 hours 15
60-80 –//– 12
40-60 –//– 7.5
30-40 –//– 4
20-30 1 time in 48 hours 7.5
10-20 –//– 4
Less than 10 –//– 3

 

To prepare the infusion solution, isotonic sodium chloride solution, 5% glucose solution, Ringer’s solution are used. The concentration of the amikacin sulfate solution when administered should not exceed 5 mg/ml. The duration of the infusion is 30-90 minutes. Intravenous injection should be carried out slowly, over 7 minutes.

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