Description

Amicyl (Amikacin) 1g. Intravenous

Ingredients

Active ingredient: Amikacin sulfate

Dosage

Dosage: The usual adult dose is 15 mg/kg/day given in divided doses every 8 hours. Dosage adjustments may be required based on kidney function.

Indications

Indications: Amicyl is indicated for the treatment of serious infections caused by susceptible strains of bacteria.

Contraindications

Contraindications: Do not use in patients with a known hypersensitivity to amikacin or any other aminoglycoside antibiotics.

Directions

Administration: Administer by intravenous infusion over a period of 30 to 60 minutes. Follow proper dilution and monitoring guidelines.

Scientific Evidence

Pharmacological Effects: Amikacin works by inhibiting bacterial protein synthesis, leading to the death of susceptible bacteria. It is effective against a wide range of gram-negative bacteria.

Clinical Trials: Clinical studies have demonstrated the efficacy of amikacin in treating severe bacterial infections, including those resistant to other antibiotics. Research by Smith et al. (2018) showed a high success rate in treating hospital-acquired pneumonia.

Additional Information

Amikacin is commonly used in hospital settings for serious infections such as sepsis, pneumonia, and urinary tract infections. It is often reserved for cases where other antibiotics have failed.

Patients receiving amikacin should be closely monitored for signs of nephrotoxicity and ototoxicity. Dosage adjustments may be necessary in patients with renal impairment to prevent adverse effects.