Aminosol NEO E 10pct 500 ml. №1 vial

active ingredients: 1000 ml of solution contain: L-isoleucine 5.0 g, L-histidine 3.0 g, L-leucine 7.4 g, L-alanine 15.0 g, L-valine 6.2 g, Glycine 14 ,0 g, L-lysine (in the form of L-lysine monoacetate 0.931 g) 6.6 g, L-proline 15.0 g, L-malic acid 9.28 g, sodium glycerophosphate 9.453 g, L-methionine 4, 3 g, calcium chloride 0.735 g, L-threonine 4.4 g, magnesium chloride hexahydrate 1.017 g, L-phenylalanine 5.1 g, potassium hydroxide 1.683 g, L-tryptophan 2.0 g, L-arginine 12.0 g , 

The total content of amino acids is 100 g/l,

total nitrogen content — 16.4 g/l;

Na+ — 60 mmol/l,

K+ — 30 mmol/l,

Ca2+ — 5 mmol/l,

Mg2+ — 5 mmol/l,

Cl- — 20 mmol/l,

acetates – 45 mmol/l,

malate- — 69.2 mmol/l,

glycerophosphates – 30 mmol/l;

excipients: water for injections.

Solution for infusions.

Main physicochemical properties: transparent colorless or pale yellow solution; theoretical osmolality — 1137 mosm/l; energy value — 1900 kJ/l (440 kcal/l); The pH of the solution is 5.7-6.3.

Solutions for parenteral nutrition. Amino acids.

PBX code В 05В А 01.

Combined drug for parenteral nutrition (partial or complete). The solution has a balanced composition of amino acids, contains eight essential amino acids, conditionally replaceable L-arginine and L-histidine, three replaceable amino acids and electrolytes. All amino acids are in the L-form, which provides the possibility of their direct participation in the biosynthesis of proteins.

Amino acids administered parenterally are widely distributed in body tissues. Used as part of complete parenteral nutrition along with glucose and fats (70/30%), amino acids reach a balanced concentration in the blood after 3 hours. Amino acids are metabolized in all tissues of the body, used in the body in the process of protein synthesis and provide the body’s energy expenditure. Retention for essential amino acids is 99% or more, for substituted amino acids it is 97% or more. Unused amino acids undergo deamination to form urea, which is then excreted in the urine. With a rapid increase in the concentration of amino acids in the blood, they can be excreted in the urine unchanged, without having time to biotransform.

Parenteral nutrition (partial or complete with the addition of fat emulsions, electrolytes and carbohydrates):

• if enteral nutrition is impossible;
• in severe cases of diseases of the digestive organs (obstruction of the gastrointestinal tract, malabsorption syndrome, inflammatory bowel diseases, pancreatitis, intestinal fistulas);
• in case of injuries;
• with burns;
• with sepsis;
• with malignant diseases;
• in preparation for surgery and after surgery.

• Hypersensitivity to any of the components of the drug;
• congenital pathologies of amino acid metabolism;
• metabolic acidosis;
• severe kidney and liver failure;
• shock;
• decompensated heart failure;
• hyperhydration;
• hyperkalemia;
• increased pathological level in the plasma of one of the electrolytes in the composition of the drug;
• acute pulmonary edema;
• pregnancy or breastfeeding;
• children’s age up to 18 years.

Uncontrolled addition of other medicinal products to Aminosol Neo E 10% solution is not recommended.

The following is a list of medicinal products with which mixing is allowed:

• antibiotics: amikacin , ampicillin, cefotaxime, ceftriaxone, doxycycline, erythromycin, gentamicin, chloramphenicol, clindamycin, netilmicin, penicillin, piperacillin, tetracycline, tobramycin, and vancomycin;
• other drugs: minophylline, cyclophosphamide, cimetidine, cytarabine, digoxin, dopamine, famotidine, phytomenadione, fluoride uracil, folic acid, furosemide, heparin, chlorpromazine, insulin, calcium gluconate, lidocaine, methyldopa, methyl prednisone, metoclopramide, methotrexate, morphine, nizatidine, norepinephrine, propranol, ranitidine and riboflavin.

It is necessary to constantly monitor the acid-alkaline and electrolyte balance, the fluid balance in the body and the state of kidney function.

In the presence of hyponatremia, attention should be paid to the level of sodium in the blood when prescribing this solution.

Administration of the drug in large quantities can cause hyperkalemia, especially in patients with diabetes. Therefore, when using this solution, small doses of insulin are prescribed to patients who are in a state of stress and to patients with diabetes mellitus of both the 1st and 2nd types.

Particular attention should be paid when administering the drug in the following cases: patients for whom the use of solutions is limited in various diseases (Aminosol Neo E 10%, solution for infusions should be administered in the amount of 1-2 liters per day), in case of sepsis, essential hypertension, diabetes diabetes, hyperthermia, liver diseases of various etiologies. When a large amount of amino acids is introduced, hepatic coma may develop.

When adding standard parenteral nutrition, it is necessary to pay attention to its compatibility with the drug.

Use only a clear solution from an undamaged bottle!

Aminosol Neo E 10% does not affect the speed of reaction when driving a vehicle or working with other mechanisms.

The drug is not used during pregnancy or breastfeeding.

Aminosol Neo E 10% is used as an intravenous infusion through one of the central veins. The dosage is individual depending on the degree of metabolic disorder and the body’s need for amino acids.

The maximum permissible rate of administration for adults is 1 ml/kg of body weight/hour, and the maximum permissible daily dose for adults is 20 ml/kg of body weight.

For a person with a body weight of 70 kg, the maximum daily dose is 1400 ml, and the recommended rate of administration is 20-35 drops/minute.

Dosage in case of liver failure: patients with liver failure cannot tolerate an increased amount of amino acids, so their protein needs are 0.8-1.1 g/kg body weight/day.

Dosage in renal insufficiency : for patients with renal insufficiency who are not on dialysis, the recommended daily protein requirement is 0.6-1.0 g/kg. For patients on dialysis, depending on the degree of hypermetabolism, the recommended dose is 1.2-2.7 g/kg/day.

The effectiveness and safety of the drug’s use in children have not been sufficiently studied, so the drug should not be prescribed to this age group of patients.

Overdose of the drug may cause volume overload of the cardiovascular system, which may develop into acute left ventricular failure and pulmonary edema, or hyperammonemia and hepatic encephalopathy, especially in patients with liver or kidney dysfunction.

There is no specific antidote, the first priority is to stop further administration of the drug and symptomatic treatment measures.

In case of an overdose of Aminosol Neo E 10% infusion solution or when the drug is administered at a high speed, the following side reactions may occur: nausea, vomiting, sweating, palpitations and tachycardia. These side effects are reversible and disappear after stopping the use of the drug or after reducing the rate of infusion.

In the case of rapid administration of Aminosol Neo E 10%, a solution for infusions, an excess of water and electrolytes, disruption of plasma components (hyperkalemia) may occur.

When Aminosol Neo E 10%, a solution for infusions into a central vein through a catheter, is injected, there may be injury at the site of needle insertion with subsequent hemorrhage and bacterial or fungal thrombophlebitis.