$21.00
Manufacturer: Slovenia
Relapse prevention:
- ventricular tachycardia, which poses a threat to the life of the patient: treatment must be started in a hospital with constant monitoring of the patient’s condition;
- symptomatic ventricular tachycardia (documented), which leads to disability;
- supraventricular tachycardia (documented), which requires treatment, and in cases where other drugs have no therapeutic effect or are contraindicated;
- ventricular fibrillation.
Treatment of supraventricular tachycardia:
- slowing or decreasing atrial fibrillation or flutter.
Ischemic heart disease and / or dysfunction of the left ventricle.
Description
Ingredients
active ingredient : amiodarone hydrochloride;
1 tablet contains amiodarone hydrochloride 200 mg;
excipients: lactose, corn starch, colloidal silicon dioxide, magnesium stearate.
Dosage form
Pills.
Basic physical and chemical properties: round biconvex tablets from white to slightly cream color, with a notch on one side.
Pharmacotherapeutic group
Class III antiarrhythmic drugs. ATX code С01В D01
Pharmacodynamics
Amiodarone is a Vaughan-Williams class III antiarrhythmic drug; however, it also has the properties of drugs of classes I, II and IV. Amiodarone mainly blocks potassium channels, to a lesser extent sodium and calcium channels, and also non-competitively blocks α- and β-adrenergic receptors. The antiarrhythmic effect of amiodarone is associated with the ability to increase the duration of the action potential of myocardial cells and the effective refractory period, accompanied by a decrease in the automatism of the sinus node, a slowdown in AV conduction, and a decrease in myocardial excitability. The antianginal effect of amiodarone is realized by reducing myocardial oxygen demand (reducing the frequency of contractions and afterload) and reducing the resistance of the coronary vessels.
Indications
Relapse prevention:
- ventricular tachycardia, which poses a threat to the life of the patient: treatment must be started in a hospital with constant monitoring of the patient’s condition;
- symptomatic ventricular tachycardia (documented), which leads to disability;
- supraventricular tachycardia (documented), which requires treatment, and in cases where other drugs have no therapeutic effect or are contraindicated;
- ventricular fibrillation.
Treatment of supraventricular tachycardia:
- slowing or decreasing atrial fibrillation or flutter.
Ischemic heart disease and / or dysfunction of the left ventricle.
Contraindications
Sinus bradycardia, sinoatrial heart block in the absence of an endocardial pacemaker (artificial pacemaker).
Weak sinus syndrome in the absence of an endocardial pacemaker (risk of sinus arrest).
Violation of antroventricular conduction of a high degree in the absence of an endocardial pacemaker.
Hyperthyroidism due to possible exacerbation when taking amiodarone.
Hypersensitivity to iodine, amiodarone or any component of Amiokordin (amiodarone hydrochloride).
Pregnancy.
breastfeeding period.
Combination with drugs that can cause paroxysmal ventricular tachycardia of the “torsades de pointes” type (with the exception of antiparasitics, antipsychotics and methadone):
- class Ia antiarrhythmic drugs (quinidine, hydroquinidine, disopyramide);
- class III antiarrhythmic drugs (sotalol, dofetilide, ibutilide);
- other drugs such as arsenic compounds, bepridil, cisapride, citalopram, escitalopram, difemanil, dolasetron (intravenous), domperidone, dronedarone, erythromycin (intravenous), levofloxacin, mechitazine, mizolastine, vincamine (intravenous), moxifloxacin, prucalopride, spiramycin ( intravenously), toremifene;
- telaprevir;
- cobicistat.
Directions
Start of treatment. The recommended dose for adults is 200 mg (1 tablet) 3 times a day for 8-10 days. In some cases, at the beginning of treatment, high doses (4-5 tablets per day) can be used, which are taken for a short period of time and under ECG control.
Supportive care. The lowest effective dose should be used. Depending on the patient’s response to the use of the drug, the maintenance dose can range from ½ tablet per day (1 tablet every 2 days) to 2 tablets per day.
Amiokordin (amiodarone hydrochloride) tablets should be taken orally with a small amount of water. Tablets can be taken during or after meals, as a single dose or divided into 2-3 doses. Tablets should be taken regularly at the same time. A missed dose should be taken as soon as possible. If the time for the next dose is already approaching, you should wait and take only the next scheduled dose (without doubling the dose).
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