Amizonchik (enisium iodide) syrup 10 mg/ml. 100 ml.

active substance: amizon (enisamium iodide);

1 ml of syrup contains 10 mg of amizon (enisamium iodide);

excipients: sodium hydrogen phosphate, dodecahydrate; citric acid, monohydrate; flavoring “Tutti-Frutti”; flavoring “Peach”; the water is purified; sorbitol solution that does not crystallize (E 420).

Syrup.

Main physical and chemical properties: transparent, slightly yellowish-greenish liquid with a specific smell.

Antiviral drugs for systemic use. ATX code J05A X.

Enisemium iodide is a derivative of isonicotinic acid. It has an inhibitory effect on influenza viruses, has interferonogenic properties, increases the body’s resistance to viral infections, has anti-inflammatory, antipyretic and analgesic effects.

Antiviral effect of Amizonchik (enisamium iodide) is related to its direct effect on the hemagglutinins of the influenza virus, as a result of which the virion loses its ability to attach to target cells for further replication.

The anti-inflammatory effect is the result of stabilization of cell and lysosomal membranes, slowing down of degranulation of basophils, antioxidant effect, normalization of the level of prostaglandins, cyclic nucleotides and energy exchange in the focus of inflammation. The antipyretic properties of this agent are caused by the effect on the thermoregulatory centers of the brain. The analgesic effect of the drug is carried out through the reticular formation of the brain stem.

Enisemium iodide strengthens persistent immunity by increasing the level of endogenous interferon in blood plasma by 3-4 times, lysozyme and increasing the titer of antibodies to infectious agents, as well as cellular immunity – due to stimulation of the functional activity of T-lymphocytes and macrophages. This agent is a powerful inducer of endogenous interferon.

After oral administration, enisamium iodide quickly enters the blood, its maximum concentration in the blood is observed 2-2.5 hours after administration. The half-life is 13.5-14 hours. The drug is metabolized in the liver, but is quickly removed from the tissues (the elimination half-life is 2-3 hours). It is excreted from the body by 90–95% with urine in the form of metabolites.

Treatment of flu and SARS.

• Hypersensitivity to the components of the drug and iodine preparations.
• The presence of allergic reactions regardless of the nature of the allergen in the anamnesis.
• Severe organic damage to the liver and kidneys.
• Tuberculosis.
• Düring’s dermatitis herpetiformis (Dühring-Brock syndrome).
• Manifest and latent hyperthyroidism.
• Autonomous adenoma, focal and diffuse autonomous foci of the thyroid gland.
• Hemorrhagic diathesis.

Amizonchik (enisamium iodide) enhances the effect of antibacterial and immunomodulatory agents. It is advisable to combine this drug with ascorbic acid and other vitamins. The use of the drug in combination with interferon is not recommended for patients with impaired thyroid function.

Amizonchik (enisamium iodide) should be prescribed with caution to patients with thyroid gland diseases, especially persons with nodular or multinodular goiter over the age of 40, due to the risk of decompensation of the functional autonomy of the thyroid gland.

The syrup contains sorbitol, so patients with hereditary intolerance to certain sugars should consult a doctor before taking this medicine. Patients with rare hereditary fructose intolerance should not take this medicine.

Sorbitol can also have a mild laxative effect. The energy value of 1 g of sorbitol is 2.6 kcal.

This medicinal product contains 1.89 mmol (or 43.5 mg) of sodium in the minimum daily dose (15 ml). Caution should be used in patients on a sodium-controlled diet.

Amizonchik (enisamium iodide) is not intended for use in this category of patients.

Use of the drug during pregnancy or breastfeeding is contraindicated.

The drug is recommended for the treatment of children aged 3 years and older. The syrup should be taken internally, preferably after a meal, with a small amount of water.

Children aged 3 to 4 years – 5 ml (50 mg) 3 times a day.

Children aged 4 to 5 years – 6 ml (60 mg) 3 times a day.

Children aged 5 to 6 years – 7 ml (70 mg) 3 times a day.

Children aged 6 to 12 should be prescribed the drug in the form of tablets. If the child cannot swallow tablets, take the drug 12 ml (120 mg) 2-3 times a day.

Do not exceed the recommended dosage.

A measuring spoon with a volume of 5 ml and a price of 1 ml is added for dosing the syrup. If you need to measure a dose that is more than 5 ml, measure first the first 5 ml of syrup, and then the rest of the dose.

The course of treatment is 5-7 days, depending on the severity of the disease and the therapeutic effect.

Amizonchik (enisamium iodide) should be used for the treatment of children aged 3 years and older.

In case of an overdose, it is possible to increase the manifestations of adverse reactions: brown coloration of the mucous membranes, vomiting, abdominal pain and diarrhea. The development of edema, erythema, acne-like and bullous rashes, and pruritus is possible.

Treatment: gastric lavage, symptomatic treatment.

Manifestations of adverse reactions are classified according to MedDRA terminology.

From the side of the immune system: hypersensitivity reactions.

From the side of the skin and subcutaneous tissue: rash, itching, urticaria, erythema, angioedema.

From the gastrointestinal tract: dry mouth, dysgeusia (bitter taste in the mouth), swelling of the oral mucosa, hypersalivation, tongue discoloration (yellowing), nausea, vomiting, diarrhea, dyspepsia, abdominal pain, pain in the upper part of the abdomen, bloating.

From the side of the respiratory system, organs of the chest and mediastinum: dyspnea, throat irritation.

From the side of the nervous system: headache, dizziness.

General disorders and disorders at the injection site : asthenia, peripheral edema.

Laboratory and instrumental data: increased blood pressure, decreased blood pressure.

2 years.

The shelf life of the drug after opening the bottle is 90 days.

Do not use the drug after the expiration date indicated on the package.

Store in the original packaging at a temperature not higher than 25 °C. Keep out of the reach of children.

100 ml in a bottle. 1 bottle and 1 measuring spoon in a pack.